Zhang Ying, Zhang Ying-Jun, Jacob Melissa R, Li Xing-Cong, Yang Chong-Ren
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Phytochemistry. 2008 Jan;69(1):264-70. doi: 10.1016/j.phytochem.2007.06.015. Epub 2007 Aug 1.
Ten steroidal saponins with cis-fused A/B ring, including a smilagenin glycoside, elephanoside A (4), and the five furostanol bisdesmosides, elephanosides B-F (6-10), were isolated from the stems of Yucca elephantipes Regel. (Agavaceae). Their structures were determined by detailed chemical and spectroscopic analysis. All the isolated compounds were tested for their in vitro antifungal and antibacterial activities. Only the two known spirostanol glycosides Ys-II (1) and Ys-IV (2) showed moderate inhibitory activity against the growth of Candida albicans and Cryptococcus neoformans.
从丝兰(龙舌兰科)的茎中分离出了十种具有顺式稠合A/B环的甾体皂苷,包括一个菝葜皂苷元糖苷、elephanoside A(4)以及五个呋甾烷醇双糖苷,elephanosides B-F(6-10)。通过详细的化学和光谱分析确定了它们的结构。对所有分离出的化合物进行了体外抗真菌和抗菌活性测试。只有两种已知的螺旋甾烷醇糖苷Ys-II(1)和Ys-IV(2)对白色念珠菌和新型隐球菌的生长表现出中等抑制活性。