Viklund Pernilla, Wengström Yvonne, Rouvelas Ioannis, Lindblad Mats, Lagergren Jesper
Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery P9:03, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Eur J Cancer. 2006 Jul;42(10):1407-14. doi: 10.1016/j.ejca.2006.02.005. Epub 2006 Jun 5.
To assess quality of life (QoL) and symptoms after oesophageal cancer surgery, a prospective nationwide population-based study was conducted in 2001-2005, including most surgically treated oesophageal cancer patients in Sweden. Six months postoperatively patients responded to an EORTC quality of life core questionnaire (QLQ C-30) with an oesophageal-specific module (OES-18). Mean scores were calculated. Mann-Whitney test was used for group comparisons. Among 282 patients, QoL was considerably reduced compared to a reference general population (P<0.001), and functioning scales were similarly negatively affected; particularly role (P<0.001) and social (P<0.001) functions. Younger patients scored worse than older. No gender differences were found. Dominating general symptoms included fatigue, appetite loss, diarrhoea, and dyspnoea, each significantly more pronounced than the general population (P<0.001). Eating problems, cough, reflux, and oesophageal pain were common oesophageal-specific symptoms. Thus, patients who undergo oesophageal cancer resection suffer greatly from reduced QoL and several general and oesophageal-specific symptoms six months postoperatively.
为评估食管癌手术后的生活质量（QoL）和症状，2001年至2005年在全国范围内开展了一项基于人群的前瞻性研究，纳入了瑞典大多数接受手术治疗的食管癌患者。术后6个月，患者对欧洲癌症研究与治疗组织（EORTC）生活质量核心问卷（QLQ C - 30）及一个食管癌特异性模块（OES - 18）进行了回答。计算了平均得分。采用曼 - 惠特尼检验进行组间比较。在282例患者中，与参考普通人群相比，生活质量显著降低（P<0.001），功能量表也受到类似的负面影响；尤其是角色功能（P<0.001）和社会功能（P<0.001）。年轻患者得分比老年患者差。未发现性别差异。主要的一般症状包括疲劳、食欲减退、腹泻和呼吸困难，每种症状都比普通人群明显更严重(P<0.001)。进食问题、咳嗽、反流和食管疼痛是常见的食管癌特异性症状。因此，接受食管癌切除术的患者在术后6个月生活质量大幅下降，并伴有多种一般症状和食管癌特异性症状。
