Mulenga Modest, Malunga Phidelis, Bennett Steve, Thuma Philip, Shulman Caroline, Fielding Katherine, Greenwood Brian
Macha Malaria Research Institute, Macha, Zambia.
Am J Trop Med Hyg. 2006 Jun;74(6):986-90.
Whether administration of folic acid to children with malaria anemia is helpful is controversial. Therefore, we conducted a randomised, placebo-controlled trial of 14 days of treatment with folic acid (1 mg/d) in Zambian children with malaria anemia treated with either sulfadoxine/pyrimethamine (SP) or atovaquone/proguanil (AP). Among children who received SP, the prevalence of parasitemia was higher in children treated with folic acid than among those given placebo at days 3, 7, and 14 after the start of treatment, and the difference at day 3 was statistically significant (P = 0.013). Folic acid treatment had no effect on parasitemia in children treated with AP. Administration of folic acid led to a small increase in packed cell volume over that seen in the placebo group at days 14 and 28 after the start of treatment.
给患疟疾贫血的儿童服用叶酸是否有益存在争议。因此，我们在赞比亚患疟疾贫血且接受周效磺胺/乙胺嘧啶（SP）或阿托伐醌/氯胍（AP）治疗的儿童中，开展了一项关于叶酸（1毫克/天）治疗14天的随机、安慰剂对照试验。在接受SP治疗的儿童中，治疗开始后第3天、第7天和第14天，接受叶酸治疗的儿童的寄生虫血症患病率高于接受安慰剂的儿童，且第3天的差异具有统计学意义（P = 0.013）。叶酸治疗对接受AP治疗的儿童的寄生虫血症没有影响。在治疗开始后的第14天和第28天，服用叶酸导致血细胞比容相比安慰剂组有小幅增加。
