Kartono Francisca, Maibach H I
Department of Dermatology, UCSF, School of Medicine, San Francisco, CA 94143, USA.
Contact Dermatitis. 2006 Jun;54(6):303-12. doi: 10.1111/j.0105-1873.2006.00792.x.
Sodium lauryl sulfate (SLS) has often been chosen as a model for irritant contact dermatitis (ICD) to study the effect of irritants in combination (1-14). Recently 'tandem', or sequential, exposures with SLS have been performed to study the mechanism of skin barrier impairment in ICD (1-6, 15). The assessment of reactions have been documented with visual scoring, transepidermal water loss (TEWL), skin colour reflectance measurements, skin blood flow; among which TEWL has been noted as the most sensitive value (16). The matched control groups were treated with either a single exposure to a single irritant or in tandem with the same irritant repeatedly. Synergistic and additive effects have been reported for various tandem pairs of irritants, however, the mechanism for both remains unclear. The results of tandem irritation studies were evaluated to define and investigate the responses produced and deduce a possible mechanism of action. Clinical ramifications, albeit complex, are discussed.
月桂醇硫酸酯钠（SLS）常被选作刺激性接触性皮炎（ICD）的模型，以研究刺激物联合作用的效果（1 - 14）。最近，已采用月桂醇硫酸酯钠进行“串联”或序贯暴露，以研究ICD中皮肤屏障受损的机制（1 - 6, 15）。已通过视觉评分、经表皮水分流失（TEWL）、皮肤颜色反射率测量、皮肤血流量记录反应评估；其中TEWL被认为是最敏感的值（16）。匹配的对照组接受单次暴露于单一刺激物或与相同刺激物反复串联处理。已报道各种刺激物串联组合存在协同和相加效应，然而，两者的机制仍不清楚。对串联刺激研究的结果进行评估，以定义和研究产生的反应，并推断可能的作用机制。尽管临床影响复杂，但也进行了讨论。
