外源环磷酸腺苷对红曲霉次级代谢产物合成的抑制作用

Repression of secondary metabolite production by exogenous cAMP in Monascus.

作者信息

Miyake Tsuyoshi, Zhang Ming-Yong, Kono Isato, Nozaki Nobuyuki, Sammoto Hiroyuki

机构信息

Industrial Technology Center of Okayama Prefecture, Haga, Okayama.

出版信息

Biosci Biotechnol Biochem. 2006 Jun;70(6):1521-3. doi: 10.1271/bbb.50686.

DOI:10.1271/bbb.50686

PMID:16794340

Abstract

The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in Monascus. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production was not influenced by cAMP on these productions, indicating that cAMP signaling might be lacking in MK-1.

摘要

环磷酸腺苷（cAMP）信号通路控制着多种生物学功能，包括丝状真菌的次级代谢。我们发现，外源性cAMP可抑制红曲霉菌中洛伐他汀、红色色素和桔霉素的产生。有趣的是，洛伐他汀和红色色素产量增加的突变体MK-1在这些产物的产生上不受cAMP的影响，这表明MK-1可能缺乏cAMP信号传导。