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J Clin Microbiol. 1991 Apr;29(4):726-30. doi: 10.1128/jcm.29.4.726-730.1991.
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6
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Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans.复发性外阴阴道念珠菌病的流行病学：白色念珠菌的鉴定与菌株分化
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In vitro susceptibilities and biotypes of Candida albicans isolates from the oral cavities of patients infected with human immunodeficiency virus.来自感染人类免疫缺陷病毒患者口腔的白色念珠菌分离株的体外药敏性及生物型
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1型人类免疫缺陷病毒感染的口腔念珠菌病患者抗真菌治疗前后的白色念珠菌生物型

Candida albicans biotypes in human immunodeficiency virus type 1-infected patients with oral candidiasis before and after antifungal therapy.

作者信息

Bruatto M, Vidotto V, Marinuzzi G, Raiteri R, Sinicco A

机构信息

Istituto di Malattie Infettive dell'Università di Torino, Ospedale Amedeo di Savoia, Italy.

出版信息

J Clin Microbiol. 1991 Apr;29(4):726-30. doi: 10.1128/jcm.29.4.726-730.1991.

DOI:10.1128/jcm.29.4.726-730.1991
PMID:1679764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC269861/
Abstract

A prospective 19-month study of 26 human immunodeficiency virus type 1-infected patients with episodes of erythematous or pseudomembranous oral candidiasis was done to evaluate the significance of Candida albicans biotypes in patients treated with antifungal therapy. Changes in the biotype of C. albicans were frequently noted in recurrent oral candidiasis. However, no correlation was found between the various biotypes and the clinical features of oral candidiasis, the clinical stage of human immunodeficiency virus type 1 infection, or the number of CD4+ lymphocytes. On the contrary, a significant correlation appeared among clinical lesion features, CD4+ cell numbers, and time of clinical disappearance of the oral lesions. Changes in the biotype of C. albicans were observed at the end of the antifungal therapy in 17 of 26 patients who had a second appearance of oral candidiasis as well as in 10 of 14 subjects who experienced a third reappearance of oral candidiasis.

摘要

对26例1型人类免疫缺陷病毒感染且患有红斑型或假膜型口腔念珠菌病的患者进行了一项为期19个月的前瞻性研究，以评估白色念珠菌生物型在接受抗真菌治疗患者中的意义。复发性口腔念珠菌病中经常会出现白色念珠菌生物型的变化。然而，未发现不同生物型与口腔念珠菌病的临床特征、1型人类免疫缺陷病毒感染的临床阶段或CD4 +淋巴细胞数量之间存在相关性。相反，临床病变特征、CD4 +细胞数量与口腔病变临床消失时间之间存在显著相关性。在26例口腔念珠菌病再次出现的患者中，有17例在抗真菌治疗结束时观察到白色念珠菌生物型的变化，在14例口腔念珠菌病第三次复发的患者中，有10例观察到了这种变化。