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Response to fluconazole by 23 patients with human immunodeficiency virus infection and oral candidiasis: pharmacological and mycological factors.23例人类免疫缺陷病毒感染合并口腔念珠菌病患者对氟康唑的反应：药理学和真菌学因素
Antimicrob Agents Chemother. 1996 Aug;40(8):1961-3. doi: 10.1128/AAC.40.8.1961.
2
Replacement of Candida albicans with C. dubliniensis in human immunodeficiency virus-infected patients with oropharyngeal candidiasis treated with fluconazole.在接受氟康唑治疗的口咽念珠菌病的人类免疫缺陷病毒感染患者中，白色念珠菌被都柏林念珠菌取代。
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Fluconazole susceptibility and strain variation of Candida albicans isolates from HIV-infected patients with oropharyngeal candidosis.来自感染人类免疫缺陷病毒（HIV）且患有口腔念珠菌病患者的白色念珠菌分离株的氟康唑敏感性及菌株变异情况
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Cross-sectional study of the susceptibility of Candida isolates to antifungal drugs and in vitro-in vivo correlation in HIV-infected patients.HIV感染患者念珠菌分离株对抗真菌药物的敏感性及体内外相关性的横断面研究。
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[Fluconazole-resistant Candida species from HIV infected patients with recurrent Candida stomatitis: cross resistance to itraconazole and ketoconazole].来自患有复发性念珠菌性口腔炎的HIV感染患者的氟康唑耐药念珠菌属：对伊曲康唑和酮康唑的交叉耐药性
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AIDS Res Hum Retroviruses. 1999 Nov 1;15(16):1413-7. doi: 10.1089/088922299309919.

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Interpretive breakpoints for fluconazole and Candida revisited: a blueprint for the future of antifungal susceptibility testing.氟康唑与念珠菌的解释性折点再探讨：抗真菌药敏试验未来的蓝图。
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Randomized, double-blind, multicenter study of caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiases.卡泊芬净与两性霉素B治疗口咽和食管念珠菌病的随机、双盲、多中心研究。
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Stable phenotypic resistance of Candida species to amphotericin B conferred by preexposure to subinhibitory levels of azoles.念珠菌属对两性霉素B的稳定表型耐药性由预先暴露于亚抑菌水平的唑类药物所致。
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Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.导致抗真菌药物耐药性的临床、细胞和分子因素。
Clin Microbiol Rev. 1998 Apr;11(2):382-402. doi: 10.1128/CMR.11.2.382.
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Review article: the therapy of gastrointestinal infections associated with the acquired immunodeficiency syndrome.综述文章：获得性免疫缺陷综合征相关胃肠道感染的治疗
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6
When should Candida isolates be tested for susceptibility to azole antifungal agents?念珠菌分离株何时应进行唑类抗真菌药物敏感性测试？
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Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1.1型人类免疫缺陷病毒血清阳性个体念珠菌分离株的体外氟康唑耐药性与治疗及症状的相关性
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2
Correlation between in vitro susceptibility of Candida albicans and fluconazole-resistant oropharyngeal candidiasis in HIV-infected patients.HIV感染患者白色念珠菌体外药敏与氟康唑耐药性口咽念珠菌病之间的相关性
Eur J Clin Microbiol Infect Dis. 1993 Dec;12(12):911-5. doi: 10.1007/BF01992164.
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Fluconazole-resistant Candida albicans.氟康唑耐药白色念珠菌
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4
Fluconazole-resistant candidosis in an HIV cohort.艾滋病病毒感染者队列中的氟康唑耐药念珠菌病
AIDS. 1994 Jun;8(6):787-92. doi: 10.1097/00002030-199406000-00010.
5
Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection.复发性口咽念珠菌病合并人类免疫缺陷病毒感染患者中白色念珠菌氟康唑耐药菌株的出现。
J Clin Microbiol. 1994 Sep;32(9):2092-8. doi: 10.1128/jcm.32.9.2092-2098.1994.
6
Clinically significant mucosal candidiasis resistant to fluconazole treatment in patients with AIDS.艾滋病患者中对氟康唑治疗耐药的具有临床意义的黏膜念珠菌病
Clin Infect Dis. 1994 Oct;19(4):684-6. doi: 10.1093/clinids/19.4.684.
7
Resistance of Candida species to fluconazole.念珠菌属对氟康唑的耐药性。
Antimicrob Agents Chemother. 1995 Jan;39(1):1-8. doi: 10.1128/AAC.39.1.1.
8
Characterization of the mycoflora from oral mucosal surfaces of some HIV-infected patients.
Oral Surg Oral Med Oral Pathol. 1990 Jun;69(6):683-7. doi: 10.1016/0030-4220(90)90348-v.
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Oral candidosis in HIV-infected patients.HIV感染患者的口腔念珠菌病。
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10
Development of resistance in candida isolates from patients receiving prolonged antifungal therapy.接受长期抗真菌治疗患者念珠菌分离株耐药性的产生
Antimicrob Agents Chemother. 1991 Nov;35(11):2302-5. doi: 10.1128/AAC.35.11.2302.

23例人类免疫缺陷病毒感染合并口腔念珠菌病患者对氟康唑的反应：药理学和真菌学因素

Response to fluconazole by 23 patients with human immunodeficiency virus infection and oral candidiasis: pharmacological and mycological factors.

作者信息

Lacassin F, Damond F, Chochillon C, Longuet P, Lebras J, Vilde J L, Leport C

机构信息

Department of Infectious Tropical Diseases, Bichat-Claude Bernard Hospital, Paris, France.

出版信息

Antimicrob Agents Chemother. 1996 Aug;40(8):1961-3. doi: 10.1128/AAC.40.8.1961.

DOI:10.1128/AAC.40.8.1961
PMID:8843316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163452/
Abstract

The MICs of fluconazole for strains of Candida species and the levels of fluconazole in serum were determined at day 0 and day 14 for 23 human immunodeficiency virus-infected patients with oral candidiasis who were treated orally with 100 mg of fluconazole per day for 14 days. Among the 23 patients, 11 (48%) were not clinically cured and had persistent isolation of Candidiasis albicans (n = 10) and/or presence of non-C. albicans (n = 6). Clinical response could be predicted by the susceptibility of the strain to fluconazole determined at day 0. All 12 patients who were cured were infected with a strain for which the MIC was < 0.78 mg/liter. All four patients who were infected with a strain for which the MIC was > 3.12 mg/liter experienced clinical failure. These data suggest that a C. albicans strain could be defined as being susceptible when the MIC of fluconazole is < 0.78 mg/liter and as being resistant when the MIC is > 3.12 mg/liter.

摘要

对23例口腔念珠菌病的人类免疫缺陷病毒感染患者进行了研究，这些患者每天口服100毫克氟康唑，持续14天，在第0天和第14天测定了念珠菌属菌株对氟康唑的最低抑菌浓度（MIC）以及血清中的氟康唑水平。在这23例患者中，11例（48%）未临床治愈，持续分离出白色念珠菌（n = 10）和/或非白色念珠菌（n = 6）。临床反应可通过第0天测定的菌株对氟康唑的敏感性来预测。所有12例治愈的患者感染的菌株MIC均< 0.78毫克/升。所有4例感染的菌株MIC> 3.12毫克/升的患者均出现临床失败。这些数据表明，当氟康唑的MIC< 0.78毫克/升时，白色念珠菌菌株可被定义为敏感，当MIC> 3.12毫克/升时可被定义为耐药。