Bartali Benedetta, Frongillo Edward A, Bandinelli Stefania, Lauretani Fulvio, Semba Richard D, Fried Linda P, Ferrucci Luigi
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853-6301, USA.
J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):589-93. doi: 10.1093/gerona/61.6.589.
Poor nutrient intake is conceptualized to be a component of frailty, but this hypothesis has been little investigated. We examined the association between low energy and nutrient intake and frailty.
We used data from 802 persons aged 65 years or older participating to the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) study. Frailty was defined by having at least two of the following criteria: low muscle strength, feeling of exhaustion, low walking speed, and reduced physical activity. The European Prospective Investigation into Cancer and nutrition (EPIC) questionnaire was used to estimate the daily intake of energy and nutrients. Low intake was defined using the value corresponding to the lowest sex-specific intake quintile of energy and specific nutrients. Adjusted logistic regression analyses were used to study the association of frailty and frailty criteria with low intakes of energy and nutrients.
Daily energy intake < or =21 kcal/kg was significantly associated with frailty (odds ratio [OR]: 1.24; 95% CI: 1.02-1.5). After adjusting for energy intake, a low intake of protein (OR: 1.98; 95% CI: 1.18-3.31); vitamins D (OR: 2.35; 95% CI: 1.48-3.73), E (OR: 2.06; 95% CI: 1.28-3.33), C (OR: 2.15; 95% CI: 1.34-3.45), and folate (OR: 1.84; 95% CI: 1.14-2.98); and having a low intake of more than three nutrients (OR: 2.12; 95% CI: 1.29-3.50) were significantly and independently related to frailty.
This study provides evidence that low intakes of energy and selected nutrients are independently associated with frailty.
营养摄入不足被认为是衰弱的一个组成部分，但这一假设很少得到研究。我们研究了低能量和营养摄入与衰弱之间的关联。
我们使用了参与基安蒂地区衰老研究（InCHIANTI，Invecchiare in Chianti, aging in the Chianti area）的802名65岁及以上老年人的数据。衰弱的定义为至少符合以下标准中的两条：肌肉力量低、疲惫感、步行速度慢和身体活动减少。使用欧洲癌症与营养前瞻性调查（EPIC）问卷来估计能量和营养的每日摄入量。低摄入量的定义是使用对应于能量和特定营养素按性别划分的最低摄入量五分位数的值。采用校正后的逻辑回归分析来研究衰弱及衰弱标准与能量和营养低摄入量之间的关联。
每日能量摄入量≤21千卡/千克与衰弱显著相关（比值比[OR]：1.24；95%置信区间：1.02 - 1.5）。在调整能量摄入量后，蛋白质摄入量低（OR：1.98；95%置信区间：1.18 - 3.31）；维生素D（OR：2.35；95%置信区间：1.48 - 3.73）、E（OR：2.06；95%置信区间：1.28 - 3.33）、C（OR：2.15；95%置信区间：1.34 - 3.45）和叶酸（OR：1.84；95%置信区间：1.14 - 2.98）；以及三种以上营养素摄入量低（OR：2.12；95%置信区间：1.29 - 3.50）均与衰弱显著且独立相关。
本研究提供了证据表明能量和特定营养素的低摄入量与衰弱独立相关。
