Cesari Matteo, Pahor Marco, Bartali Benedetta, Cherubini Antonio, Penninx Brenda W J H, Williams G Rhys, Atkinson Hal, Martin Antonio, Guralnik Jack M, Ferrucci Luigi
Sticht Center on Aging, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Am J Clin Nutr. 2004 Feb;79(2):289-94. doi: 10.1093/ajcn/79.2.289.
Muscle strength and physical performance in old age might be related to the oxidative damage caused by free radicals.
The objective was to assess the correlation of plasma concentrations and daily dietary intakes of antioxidants with skeletal muscle strength and physical performance in elderly persons.
This study is part of the Invecchiare in Chianti (InCHIANTI) study, which was conducted in 986 Italians aged > or = 65 y. Physical performance was assessed on the basis of walking speed, ability to rise from a chair, and standing balance. Knee extension strength was assessed with a hand-held dynamometer. The European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire was used to evaluate the daily dietary intakes of vitamin C, vitamin E, beta-carotene, and retinol. Plasma alpha- and gamma-tocopherol concentrations were measured. Adjusted linear regression analyses were used to calculate regression coefficients per SD increase in plasma concentrations and daily dietary intakes.
In adjusted analyses, plasma alpha-tocopherol was significantly correlated with knee extension (beta = 0.566, P = 0.003) and the summary physical performance score (beta = 0.044, P = 0.008). Plasma gamma-tocopherol was associated only with knee extension strength (beta = 0.327, P = 0.04). Of the daily dietary intake measures, vitamin C and beta-carotene were significantly correlated with knee extension strength, and vitamin C was significantly associated with physical performance (beta = 0.029, P = 0.04).
Plasma antioxidant concentrations correlate positively with physical performance and strength. Higher dietary intakes of most antioxidants, especially vitamin C, appear to be associated with higher skeletal muscular strength in elderly persons.
老年人的肌肉力量和身体机能可能与自由基引起的氧化损伤有关。
评估老年人血浆抗氧化剂浓度和每日膳食摄入量与骨骼肌力量及身体机能之间的相关性。
本研究是基安蒂地区老龄化（InCHIANTI）研究的一部分，该研究对986名年龄≥65岁的意大利人进行。身体机能根据步行速度、从椅子上起身的能力和站立平衡能力进行评估。使用手持测力计评估膝关节伸展力量。采用欧洲癌症与营养前瞻性调查（EPIC）问卷评估维生素C、维生素E、β-胡萝卜素和视黄醇的每日膳食摄入量。测量血浆α-生育酚和γ-生育酚浓度。采用调整后的线性回归分析计算血浆浓度和每日膳食摄入量每增加1个标准差的回归系数。
在调整分析中，血浆α-生育酚与膝关节伸展显著相关（β = 0.566，P = 0.003）以及综合身体机能评分显著相关（β = 0.044，P = 0.008）。血浆γ-生育酚仅与膝关节伸展力量相关（β = 0.327，P = 0.04）。在每日膳食摄入量指标中，维生素C和β-胡萝卜素与膝关节伸展力量显著相关，维生素C与身体机能显著相关（β = 0.029，P = 0.04）。
血浆抗氧化剂浓度与身体机能和力量呈正相关。大多数抗氧化剂，尤其是维生素C的较高膳食摄入量似乎与老年人较高的骨骼肌力量有关。
