Ndung'u J M, Eckersall P D, Jennings F W
Department of Veterinary Medicine, University of Glasgow, Bearsden, U.K.
Acta Trop. 1991 Jun;49(2):77-86. doi: 10.1016/0001-706x(91)90055-o.
Plasma concentrations of the acute phase proteins (APP), C-reactive protein (CRP) and haptoglobin (Hp), increased markedly following experimental infection of dogs with Trypanosoma brucei. The highest concentrations of CRP were observed immediately after peaks of parasitaemia. Treatment with curative doses of the trypanocidal drug suramin caused a rapid decrease in CRP. Relapse infections after subcurative treatment were followed by a reappearance of high plasma CRP concentrations. Haptoglobin remained elevated during the course of the disease. Curative treatment with suramin caused a gradual but slow decrease in Hp while subcurative treatment caused no significant changes. Thus, the estimation of CRP was useful in determining the presence of active infection and the success of chemotherapy. High Hp levels in severely anaemic dogs indicated that intravascular haemolysis does not contribute significantly to the anaemia associated with T. brucei infections in dogs. These conclusions need confirmation from a larger experiment.
在用布氏锥虫实验感染犬后，急性期蛋白（APP）、C反应蛋白（CRP）和触珠蛋白（Hp）的血浆浓度显著升高。在寄生虫血症高峰后立即观察到CRP的最高浓度。用治疗剂量的杀锥虫药物苏拉明进行治疗导致CRP迅速下降。亚治疗剂量治疗后的复发感染伴随着血浆CRP高浓度的再次出现。在疾病过程中触珠蛋白一直保持升高。用苏拉明进行根治性治疗导致Hp逐渐但缓慢下降，而亚治疗剂量治疗则未引起显著变化。因此，CRP的测定有助于确定是否存在活动性感染以及化疗是否成功。严重贫血犬的高Hp水平表明，血管内溶血对犬布氏锥虫感染相关贫血的影响不大。这些结论需要通过更大规模的实验来证实。
