Lai Timothy Y Y, Ngai Jasmine W S, Chan Wai-Man, Lam Dennis S C
Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong.
Doc Ophthalmol. 2006 May;112(3):177-87. doi: 10.1007/s10633-006-9006-0. Epub 2006 Jun 28.
To evaluate the effects of hydroxychloroquine on visual field and multifocal electroretinography (mfERG) and their correlations in patients taking hydroxychloroquine.
This was a cross-sectional study in which patients on hydroxychloroquine therapy underwent automated 10-2 threshold static visual field examination and mfERG recordings. Non-parametric unadjusted and age-adjusted Spearman correlation coefficients rho were calculated between the cumulative dose of hydroxychloroquine and the visual field mean deviation (MD) and pattern standard deviation (PSD) values; and the mfERG response amplitudes and peak latencies. Correlation analysis was also performed between the visual field MD and PSD values and the mfERG response amplitudes and peak latencies.
A total of 26 eyes in 13 patients were analyzed. The mean duration of hydroxychloroquine therapy was 4.9 years and the mean cumulative dose was 574 g. No significant correlation was found between the cumulative dose of hydroxychloroquine and the visual field MD and PSD values. There were significant correlations between the cumulative dose of hydroxychloroquine and mfERG N1 and P1 response amplitudes for the central rings (ring 1-3). The correlations between the dose of hydroxychloroquine and mfERG N1 and P1 response amplitudes were strongest for the paracentral ring 2 (rho =-0.63 and rho =-0.62, respectively, P = 0.001). Significant correlations were also found between the visual field MD values and mfERG response amplitudes of various ring eccentricities.
In patients on hydroxychloroquine, mfERG response amplitude correlated with both the 10-2 visual field MD values and with the cumulative dose of hydroxychloroquine used. The use of mfERG can provide objective measurement of retinal function in patients on hydroxychloroquine and may provide supplementary quantitative information to visual field findings.
评估羟氯喹对服用羟氯喹患者视野及多焦视网膜电图（mfERG）的影响及其相关性。
这是一项横断面研究，对接受羟氯喹治疗的患者进行自动10-2阈值静态视野检查和mfERG记录。计算羟氯喹累积剂量与视野平均偏差（MD）和模式标准偏差（PSD）值之间，以及与mfERG反应振幅和峰潜伏期之间的非参数未调整和年龄调整Spearman相关系数rho。还对视野MD和PSD值与mfERG反应振幅和峰潜伏期进行了相关性分析。
共分析了13例患者的26只眼。羟氯喹治疗的平均时长为4.9年，平均累积剂量为574克。未发现羟氯喹累积剂量与视野MD和PSD值之间存在显著相关性。羟氯喹累积剂量与中央环（环1-3）的mfERG N1和P1反应振幅之间存在显著相关性。羟氯喹剂量与旁中心环2的mfERG N1和P1反应振幅之间的相关性最强（rho分别为-0.63和-0.62，P = 0.001）。还发现不同环偏心度的视野MD值与mfERG反应振幅之间存在显著相关性。
在服用羟氯喹的患者中，mfERG反应振幅与10-2视野MD值以及所用羟氯喹的累积剂量均相关。mfERG的应用可为服用羟氯喹患者的视网膜功能提供客观测量，并可能为视野检查结果提供补充定量信息。
