Kawano Junko, Tomidokoro Atsuo, Mayama Chihiro, Kunimatsu Shiho, Tomita Goji, Araie Makoto
Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Am J Ophthalmol. 2006 Jul;142(1):40-45. doi: 10.1016/j.ajo.2006.01.087.
To evaluate the correlation between the superior or inferior half area of parapapillary atrophy (PPA) and the corresponding hemifield visual field damage (VFD) in normal-tension glaucoma.
Cross-sectional study.
patients: One hundred nine eyes of 109 consecutive patients with normal-tension glaucoma. observation procedures: Topography parameters of the optic nerve head and PPA (zone beta) area were obtained with the Heidelberg Retina Tomograph (HRT), and VFD was evaluated with the 30 to 2 program of Humphrey Field Analyzer. The HRT parameters and PPA area were determined separately in superior and inferior half regions. main outcome measures: Partial correlation coefficients of the superior and inferior areas of PPA with refractive error, axial length, HRT parameters, and corresponding hemifield VFD.
In simple correlation analyses, significant correlation was found between the inferior PPA area and the superior hemifield VFD (Spearman rank correlation coefficient; Rs = -0.32; P < .001) but not between the superior PPA area and the inferior hemifield VFD (Rs = 0.05; P = .6). Age, refractive error, axial length, and height variation contour were associated significantly with the total, superior, and inferior areas of PPA, respectively (P < .01). Multiple regression analyses showed that the superior PPA area was associated significantly with only axial length (P < .001), and the inferior PPA area was associated significantly with the axial length and the superior hemifield VFD (P < .001).
In patients with normal-tension glaucoma, only the inferior half area of PPA correlated significantly with glaucomatous VFD. Axial length and myopia were associated with both the superior and inferior half areas of PPA.
评估正常眼压性青光眼中视乳头旁萎缩（PPA）上半区或下半区面积与相应半视野视野损害（VFD）之间的相关性。
横断面研究。
患者：109例连续的正常眼压性青光眼患者的109只眼。观察程序：使用海德堡视网膜断层扫描仪（HRT）获取视神经乳头的地形参数和PPA（β区）面积，并用Humphrey视野分析仪的30-2程序评估VFD。HRT参数和PPA面积分别在上半区和下半区测定。主要观察指标：PPA上半区和下半区面积与屈光不正、眼轴长度、HRT参数及相应半视野VFD的偏相关系数。
在简单相关性分析中，发现PPA下半区面积与上半视野VFD之间存在显著相关性（Spearman等级相关系数；Rs = -0.32；P <.001），而PPA上半区面积与下半视野VFD之间无显著相关性（Rs = 0.05；P =.6）。年龄、屈光不正、眼轴长度和高度变化轮廓分别与PPA的总面积、上半区和下半区显著相关（P <.01）。多元回归分析显示，PPA上半区面积仅与眼轴长度显著相关（P <.001），而PPA下半区面积与眼轴长度和上半视野VFD显著相关（P <.001）。
在正常眼压性青光眼患者中，仅PPA的下半区面积与青光眼性VFD显著相关。眼轴长度和近视与PPA的上半区和下半区均相关。
