Iwase Aiko, Sawaguchi Shoichi, Sakai Hiroshi, Tanaka Kenji, Tsutsumi Tae, Araie Makoto
Tajimi Iwase Eye Clinic, Crystal Plaza Tajimi, 3-101-1 Honmachi, Tajimi, Gifu, 507-0033, Japan.
Department of Ophthalmology, University of the Ryukyus, Graduate School of Medicine, Okinawa, Japan.
Jpn J Ophthalmol. 2017 May;61(3):223-229. doi: 10.1007/s10384-017-0499-8. Epub 2017 Feb 9.
To report reference data for optic disc, neuroretinal rim and β-peripapillary atrophy (β-PPA) in normal Japanese.
In the Kumejima study, all participants underwent disc stereo-photography; 2208 normal subjects had good-quality disc stereo and β-PPA photographs OU. The disc and rim area and the area and angular extent of β-PPA were evaluated by computer-assisted planimetry.
The disc, rim, and β-PPA area and its angular extent OD (OS) averaged 2.54 ± 0.50 (2.53 ± 0.49), 1.67 ± 0.29 (1.67 ± 0.30), 0.47 ± 0.66 (0.42 ± 0.59) mm, and 99 ± 85 (92 ± 82) degrees (mean ± standard deviation) with bilateral Pearson's correlation coefficient of 0.890, 0.769, 0.679 and 0.632 (P < 0.001), respectively, while the 95th percentiles of the absolute inter-eye differences were 0.48, 0.41, 0.96 mm, and 153°. The correlation coefficient between β-PPA area and its angular extent was 0.963 (P < 0.001). Age showed negative correlation with the rim area and positive correlation with β-PPA area (P < 0.001). Among ocular factors, disc area showed positive correlation and intraocular pressure negative correlation with the rim area (P ≤ 0.001), axial length and disc area positive correlation with β-PPA area (P < 0.001 and P = 0.051).
The averages and distribution of the optic disc and rim area, β-PPA area and its angular extent in normal Japanese are reported, which will facilitate screening of glaucoma in Japanese. In normal Japanese eyes, the disc size and intraocular pressure significantly correlated with the rim area, and the axial length with β-PPA area.
报告正常日本人视盘、神经视网膜边缘和β-视乳头周围萎缩（β-PPA）的参考数据。
在久米岛研究中，所有参与者均接受了视盘立体摄影；2208名正常受试者双眼拥有高质量的视盘立体图像和β-PPA图像。视盘和边缘区域以及β-PPA的面积和角度范围通过计算机辅助平面测量法进行评估。
视盘、边缘和β-PPA区域及其角度范围右眼（左眼）的平均值分别为2.54±0.50（2.53±0.49）、1.67±0.29（1.67±0.30）、0.47±0.66（0.42±0.59）mm和99±85（92±82）度（均值±标准差），双侧Pearson相关系数分别为0.890、0.769、0.679和0.632（P<0.001），而两眼间绝对差异的第95百分位数分别为0.48、0.41、0.96mm和153°。β-PPA面积与其角度范围之间的相关系数为0.963（P<0.001）。年龄与边缘区域呈负相关，与β-PPA区域呈正相关（P<0.001）。在眼部因素中，视盘面积与边缘区域呈正相关，眼压与边缘区域呈负相关（P≤0.001），眼轴长度和视盘面积与β-PPA区域呈正相关（P<0.001和P=0.051）。
报告了正常日本人视盘和边缘区域、β-PPA区域及其角度范围的平均值和分布情况，这将有助于日本人青光眼的筛查。在正常日本人眼中，视盘大小和眼压与边缘区域显著相关，眼轴长度与β-PPA区域显著相关。
