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[吲哚菁绿使用与未使用情况下内界膜剥除的比较。玻璃体切除术后特发性黄斑裂孔的功能结果]

[Comparison of ILM peeling with and without the use of indocyanine green. Functional results for idiopathic macular hole after pars plana vitrectomy].

作者信息

Rüfer F, Frimpong-Boateng A, Bunse A, Roider J

机构信息

Klinik für Ophthalmologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Hegewischstrasse 2, 24105, Kiel, Germany.

出版信息

Ophthalmologe. 2007 Jan;104(1):54-9. doi: 10.1007/s00347-006-1379-7.

Abstract

BACKGROUND

Pars plana vitrectomy with internal limiting membrane (ILM) peeling is the best known therapy for idiopathic macular holes. Indocyanine green (ICG) is useful for staining the ILM, although there is a dose related toxic effect on the inner retinal layers. We compared outcome results with and without the use of ICG.

METHOD

Data from 61 patients with idiopathic macular holes, who underwent macular hole surgery were analyzed retrospectively. ICG was used on 36 eyes while for 25 eyes it was not used. After calculating logMAR, differences in visual acuity between both groups were analyzed for significance using the Mann-Whitney-U-Test.

RESULTS

The logMAR for the entire group was 0.71+/-0.30 (20/100) preoperatively, after 1 month 0.71+/-0.36 (20/100), after 3 months 0.57+/-0.26 (20/80), after 6 months 0.54+/-0.38 (20/66) and after 12 months 0.36+/-0.32 (20/50). There were no significant differences between groups.

CONCLUSION

There seem to be no significant differences in the development of visual acuity and the occlusion rate between patients treated with or without the use of ICG.

摘要

背景

玻璃体后皮质切除术联合内界膜(ILM)剥除术是特发性黄斑裂孔最著名的治疗方法。吲哚菁绿(ICG)可用于染色ILM,尽管其对视网膜内层存在剂量相关的毒性作用。我们比较了使用和未使用ICG的治疗结果。

方法

回顾性分析61例行黄斑裂孔手术的特发性黄斑裂孔患者的数据。36只眼使用了ICG,25只眼未使用。计算logMAR后,使用曼-惠特尼-U检验分析两组之间视力差异的显著性。

结果

整个组术前logMAR为0.71±0.30(20/100),术后1个月为0.71±0.36(20/100),术后3个月为0.57±0.26(20/80),术后6个月为0.54±0.38(20/66),术后12个月为0.36±0.32(20/50)。两组之间无显著差异。

结论

使用或未使用ICG治疗的患者在视力发展和闭合率方面似乎没有显著差异。

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