Law Dennis K S, Lorange Manon, Ringuette Louise, Dion Réjean, Giguère Michel, Henderson Averil M, Stoltz Jan, Zollinger Wendell D, De Wals Philippe, Tsang Raymond S W
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
J Clin Microbiol. 2006 Aug;44(8):2743-9. doi: 10.1128/JCM.00601-06.
During periods of endemic meningococcal disease, serogroup B Neisseria meningitidis is responsible for a significant percentage of invasive diseases, and no particular clone or strain predominates (F. E. Ashton and D. A. Caugant, Can. J. Microbiol. 47: 293-289, 2001), However, in the winter of 2004 to 2005, a cluster of serogroup B meningococcal disease occurred in one region in the province of Québec, Canada. The N. meningitidis strain responsible for this cluster of cases was identified as sequence type ST-269 with the antigenic formula B:17:P1.19. Retrospective analysis of isolates from 2000 onwards showed that this clone first emerged in the province of Québec in 2003. The emergence of this clone of serogroup B meningococci occurred after a mass vaccination against serogroup C N. meningitidis, suggesting possible capsule replacement.
在流行性脑膜炎球菌病流行期间，B群脑膜炎奈瑟菌导致了相当比例的侵袭性疾病，且没有特定的克隆株或菌株占主导地位（F.E. 阿什顿和D.A. 考根特，《加拿大微生物学杂志》47: 293 - 289，2001年）。然而，在2004年至2005年冬季，加拿大魁北克省的一个地区发生了一群B群脑膜炎球菌病病例。导致这一群病例的脑膜炎奈瑟菌菌株被鉴定为序列型ST - 269，抗原公式为B:17:P1.19。对2000年起分离株的回顾性分析表明，该克隆株于2003年首次在魁北克省出现。这种B群脑膜炎球菌克隆株的出现发生在针对C群脑膜炎奈瑟菌的大规模疫苗接种之后，提示可能存在荚膜置换。
