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在加拿大魁北克引起侵袭性脑膜炎球菌病的C群ET-15脑膜炎球菌独特变体（抗原公式为C:2a:P1.7,1）的表型和基因特征

Phenotypic and genetic characterization of a unique variant of serogroup C ET-15 meningococci (with the antigenic formula C:2a:P1.7,1) causing invasive meningococcal disease in Quebec, Canada.

作者信息

Tsang Raymond S W, Tsai Chao Ming, Zhu Peixuan, Ringuette Louise, Lorange Manon, Law Dennis K S

机构信息

CNS Infection Division, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba.

出版信息

J Clin Microbiol. 2004 Apr;42(4):1460-5. doi: 10.1128/JCM.42.4.1460-1465.2004.

DOI:10.1128/JCM.42.4.1460-1465.2004
PMID:15070989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC387618/
Abstract

Serogroup C Neisseria meningitidis belonging to the electrophoretic type (ET) ET-15, a variant of ET-37, is endemic in Canada. Like other serogroup C ET-37 meningococci, the endemic ET-15 strains are usually found to carry the serotype and serosubtype antigens of 2a:P1.5,2. In 2001, a sudden increase in the number of cases of serogroup C meningococcal disease in Quebec, Canada, was caused by an antigenic variant of the ET-15 strain. This antigenic variant carries the unique serosubtype marker of P1.7,1. Strains of C:2a:P1.7,1 meningococci were not isolated in Canada in large numbers prior to 2001, and the characteristics of these meningococcal strains linked to an outbreak in Quebec, Canada, are described in the present study.

摘要

属于电泳型（ET）ET-15（ET-37的一个变体）的C群脑膜炎奈瑟菌在加拿大呈地方性流行。与其他C群ET-37脑膜炎球菌一样，地方性流行的ET-15菌株通常携带2a:P1.5,2的血清型和血清亚型抗原。2001年，加拿大魁北克省C群脑膜炎球菌病病例数突然增加，是由ET-15菌株的一种抗原变体引起的。这种抗原变体携带独特的P1.7,1血清亚型标记。2001年之前，C:2a:P1.7,1脑膜炎球菌菌株在加拿大未大量分离，本研究描述了与加拿大魁北克省一次暴发相关的这些脑膜炎球菌菌株的特征。

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