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Comparison of results of voriconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global antifungal surveillance program.伏立康唑纸片扩散法检测念珠菌属的结果与ARTEMIS全球抗真菌监测项目中一家中央参考实验室的结果比较。

J Clin Microbiol. 2005 Oct;43(10):5208-13. doi: 10.1128/JCM.43.10.5208-5213.2005.

2

A retrospective Evaluation of fluconazole for the treatment of Candida glabrata fungemia.氟康唑治疗光滑念珠菌血症的回顾性评估

Clin Ther. 2005 Aug;27(8):1228-37. doi: 10.1016/j.clinthera.2005.08.007.

3

Rapid acquisition of stable azole resistance by Candida glabrata isolates obtained before the clinical introduction of fluconazole.在氟康唑临床应用之前分离得到的光滑念珠菌菌株迅速获得稳定的唑类耐药性。

Antimicrob Agents Chemother. 2005 Feb;49(2):783-7. doi: 10.1128/AAC.49.2.783-787.2005.

4

Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance.在一项医院抗真菌耐药性调查期间收集的光滑念珠菌临床分离株中唑类耐药机制。

Antimicrob Agents Chemother. 2005 Feb;49(2):668-79. doi: 10.1128/AAC.49.2.668-679.2005.

5

Mechanism of increased fluconazole resistance in Candida glabrata during prophylaxis.光滑念珠菌在预防过程中对氟康唑耐药性增加的机制。

Antimicrob Agents Chemother. 2004 May;48(5):1773-7. doi: 10.1128/AAC.48.5.1773-1777.2004.

6

Guidelines for treatment of candidiasis.念珠菌病治疗指南。

Clin Infect Dis. 2004 Jan 15;38(2):161-89. doi: 10.1086/380796. Epub 2003 Dec 19.

7

Multilocus sequence typing of Candida glabrata reveals geographically enriched clades.光滑念珠菌的多位点序列分型揭示了地理上富集的进化枝。

J Clin Microbiol. 2003 Dec;41(12):5709-17. doi: 10.1128/JCM.41.12.5709-5717.2003.

8

Multiple patterns of resistance to fluconazole in Candida glabrata isolates from a patient with oropharyngeal candidiasis receiving head and neck radiation.来自一名接受头颈部放疗的口咽念珠菌病患者的光滑念珠菌分离株中对氟康唑的多种耐药模式

J Clin Microbiol. 2003 Feb;41(2):619-22. doi: 10.1128/JCM.41.2.619-622.2003.

9

Maternal sepsis and intrauterine fetal death resulting from Candida tropicalis chorioamnionitis in a woman with a retained intrauterine contraceptive device.一名宫内节育器残留妇女因热带念珠菌绒毛膜羊膜炎导致的产妇败血症和宫内胎儿死亡。

Acta Obstet Gynecol Scand. 2002 Oct;81(10):981-2. doi: 10.1034/j.1600-0412.2002.811014.x.

10

The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents.光滑念珠菌的ATP结合盒转运蛋白基因CgCDR1与临床分离株对唑类抗真菌药物的耐药性有关。

Antimicrob Agents Chemother. 1999 Nov;43(11):2753-65. doi: 10.1128/AAC.43.11.2753.

复发性真菌血症病例中光滑念珠菌的唑类耐药性

Azole resistance of Candida glabrata in a case of recurrent fungemia.

作者信息

Posteraro Brunella, Tumbarello Mario, La Sorda Marilena, Spanu Teresa, Trecarichi Enrico Maria, De Bernardis Flavia, Scoppettuolo Giancarlo, Sanguinetti Maurizio, Fadda Giovanni

机构信息

Department of Microbiology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome 00168, Italy.

出版信息

J Clin Microbiol. 2006 Aug;44(8):3046-7. doi: 10.1128/JCM.00526-06.

DOI:10.1128/JCM.00526-06

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1594598/

Abstract

We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.

摘要

我们描述了一例复发性光滑念珠菌血症病例，该病例对氟康唑治疗无反应。与原始分离株相比，该免疫功能正常患者血液和阴道培养物的治疗后分离株对唑类耐药，且CgCDR1/CgCDR2外排泵的表达上调。两性霉素B治疗根除了感染。