Mensah Abraham Y, Houghton Peter J, Dickson Rita A, Fleischer T C, Heinrich M, Bremner P
Department of Pharmacognosy, Faculty of Pharmacy, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Phytother Res. 2006 Nov;20(11):941-4. doi: 10.1002/ptr.1978.
Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC(50) value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 microg/mL and 10 microg/mL. The extracts showed no inhibition of NF-kappaB at 100 microg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.
白花紫露草和苞萼木在加纳阿散蒂传统医学中被用作伤口愈合剂。白花紫露草全草和苞萼木树皮的甲醇提取物表现出一定程度的抗菌活性，白花紫露草对毛癣菌属表现出选择性抗真菌活性。提取物分别以1.39 mg/mL和0.24 mg/mL的IC(50)值降低了牛脑提取物的过氧化作用。此外，提取物在1微克/毫升至10微克/毫升的浓度下，通过保护MRC - 5细胞免受过氧化氢诱导的氧化损伤，还表现出显著的抗氧化活性。提取物在100微克/毫升时未显示对NF-κB的抑制作用。抗氧化活性和抗菌活性表明，这些植物在伤口愈合中的应用可能基于其成分的抗氧化和防腐作用。
