Wolk Alicja, Larsson Susanna C, Johansson Jan-Erik, Ekman Peter
Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
JAMA. 2006 Sep 20;296(11):1371-6. doi: 10.1001/jama.296.11.1371.
The epidemiological evidence that fatty fish consumption may be associated with the lower risk of several cancers is not consistent and no studies of renal cell carcinoma (RCC) exist.
To examine the association between fatty and lean fish consumption and risk of RCC in women.
DESIGN, SETTING, AND PARTICIPANTS: The Swedish Mammography Cohort, a population-based prospective cohort study of 61,433 women aged 40 to 76 years without previous diagnosis of cancer at baseline (March 1, 1987-December 14, 1990). Participants filled in a food frequency questionnaire at baseline and in September 1997.
Incident renal cell carcinoma.
During a mean of 15.3 years (940,357 person-years) of follow-up between 1987 and 2004, 150 incident RCC cases were diagnosed. After adjustment for potential confounders, an inverse association of fatty fish consumption with the risk of RCC was found (P for trend = .02), but no association was found with lean fish consumption. Compared with no consumption, the multivariate rate ratio (RR) was 0.56 (95% confidence interval [CI], 0.35-0.91) for women eating fatty fish once a week or more. Compared with women consistently reporting no fish consumption, the multivariate RR was 0.26 (95% CI, 0.10-0.67) for those women reporting consistent consumption of fatty fish at baseline and 1997 (based on a subset of 36 664 women who filled in the baseline and 1997 questionnaires, with 40 incident RCC cases during the 1998-2004 follow-up period).
Our study suggests that consumption of fatty fish may reduce the occurrence of RCC in women.
食用富含脂肪的鱼类可能与多种癌症风险降低相关的流行病学证据并不一致，且尚无关于肾细胞癌（RCC）的研究。
研究食用富含脂肪的鱼类和瘦鱼与女性肾细胞癌风险之间的关联。
设计、地点和参与者：瑞典乳腺X线摄影队列研究，这是一项基于人群的前瞻性队列研究，纳入了61433名年龄在40至76岁之间、基线时（1987年3月1日至1990年12月14日）未被诊断患有癌症的女性。参与者在基线时和1997年9月填写了食物频率问卷。
新发肾细胞癌。
在1987年至2004年平均15.3年（940357人年）的随访期间，共诊断出150例新发肾细胞癌病例。在对潜在混杂因素进行调整后，发现食用富含脂肪的鱼类与肾细胞癌风险呈负相关（趋势P值=0.02），但未发现与食用瘦鱼有关联。与不食用相比，每周食用一次或更多富含脂肪鱼类的女性的多变量率比（RR）为0.56（95%置信区间[CI]，0.35 - 0.91）。与一直报告不食用鱼类的女性相比，在基线和1997年报告持续食用富含脂肪鱼类的女性（基于36664名填写了基线和1997年问卷的女性子集，在1998 - 2004年随访期间有40例新发肾细胞癌病例）的多变量RR为0.26（95%CI，0.10 - 0.67）。
我们的研究表明，食用富含脂肪的鱼类可能会降低女性肾细胞癌的发生率。
