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2
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Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.巨噬细胞中亚硝酸盐、硝酸盐和N-亚硝胺的合成：呼吸爆发的前体及其作用
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内毒素对大鼠脑、肺和肝一氧化氮合酶的差异诱导作用

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.

作者信息

Knowles R G, Merrett M, Salter M, Moncada S

机构信息

Wellcome Research Laboratories, Beckenham, Kent, U.K.

出版信息

Biochem J. 1990 Sep 15;270(3):833-6. doi: 10.1042/bj2700833.

DOI:10.1042/bj2700833
PMID:1700698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1131810/
Abstract

Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.

摘要

已发现大鼠脑中的一氧化氮（NO）合酶是组成型且依赖Ca2+的。大鼠肺或肝脏（主要在实质细胞中）中的该酶不是组成型的，而是由内毒素处理诱导产生的，并且不依赖Ca2+。因此，大鼠脑、肝脏和肺中的NO合酶在性质和调节方面都有所不同。