Park Jeong Sook, Hwang Seock Yeon, Lee Won Suk, Yu Kee Won, Paek Kee Yoeup, Hwang Bang Yeon, Han Kun
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea.
Arch Pharm Res. 2006 Sep;29(9):800-7. doi: 10.1007/BF02974082.
This study examined the possibility of using a tissue cultured root of wild Panax ginseng (tcwPG) as a fertility agent. The effect of tcwPG on spermatogenesis was studied using male rats. The tcwPG crude powder was administered orally to 7-week-old rats over a 6-week period. The number of sperm in the testes and epididymides was significantly higher than the control. A histological examination did not reveal any morphological changes in the testes from the tcwPG powder treated rats. Moreover, there were no significant differences in the weights of the heart, spleen, liver, kidney, brain, testes and epididymides. Oligospermia was also induced by administering 2,3,7,8-tetrachlorodaibenzo-p-dioxin (TCDD) to the rats in order to estimate the feasibility of using tcwPG as treatment for infertility caused by spermatogenic disorders. After exposing the rats to TCDD, the tcwPG saponin fraction treated rats showed some improvement in the body weight, sperm number and testis morphology. It was estimated that tcwPG had feasibility as a therapeutic agent on spermatogenic disorder.
本研究探讨了使用野生人参组织培养根（tcwPG）作为生育剂的可能性。利用雄性大鼠研究了tcwPG对精子发生的影响。将tcwPG粗粉口服给予7周龄大鼠，持续6周。睾丸和附睾中的精子数量显著高于对照组。组织学检查未发现经tcwPG粉末处理的大鼠睾丸有任何形态变化。此外，心脏、脾脏、肝脏、肾脏、大脑、睾丸和附睾的重量没有显著差异。为了评估使用tcwPG治疗由精子发生障碍引起的不孕症的可行性，还通过给大鼠施用2,3,7,8-四氯二苯并对二恶英（TCDD）诱导少精子症。在大鼠接触TCDD后，经tcwPG皂苷部分处理的大鼠在体重、精子数量和睾丸形态方面有一些改善。据估计，tcwPG作为治疗精子发生障碍的药物具有可行性。
