Park Hyun Jun, Choe Sangmin, Park Nam Cheol
Department of Urology, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea.
Medical Research Institute of Pusan National University Hospital, Busan, 602-739, Republic of Korea.
Chin J Integr Med. 2016 Jul;22(7):490-5. doi: 10.1007/s11655-015-2139-9. Epub 2015 May 12.
To investigate the effects of Korean red ginseng (KRG) on semen parameters in male infertility patients in a randomized, double-blind, placebo-controlled study.
A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups: non-varicocelectomy (V)+placebo (P) group, V+P group, non-V+KRG group (1.5-g KRG daily), and V+KGR group (1.5-g KRG daily). Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks.
All groups but not the non-V+P group, showed significant improvements in sperm concentrations, motility, morphology, and viability at the end of the study. However, there were no significant differences in serum follicle-stimulating hormone, luteinizing hormone, and testosterone among groups. The incidence of adverse events was low, and all events were assumed to be unrelated to the treatments administered.
Although the exact mechanism by which KRG improves spermatogenesis remains unclear, KRG may be a useful agent for the treatment of male infertility. Nevertheless, additional studies to evaluate the optimal dose and duration of treatment are needed.
在一项随机、双盲、安慰剂对照研究中，探讨高丽参（KRG）对男性不育患者精液参数的影响。
2011年4月至2012年2月共招募了80例患有精索静脉曲张的男性不育患者。然后将受试者分为以下四组：非精索静脉曲张切除术（V）+安慰剂（P）组、V+P组、非V+KRG组（每日1.5克KRG）和V+KGR组（每日1.5克KRG）。12周后，对每个治疗组进行精液分析并测量激素水平。
在研究结束时，除了非V+P组外，所有组的精子浓度、活力、形态和存活率均有显著改善。然而，各组之间血清促卵泡激素、黄体生成素和睾酮水平无显著差异。不良事件发生率较低，且所有事件均被认为与所给予的治疗无关。
尽管KRG改善精子发生的确切机制尚不清楚，但KRG可能是治疗男性不育的一种有用药物。然而，需要进一步研究以评估最佳治疗剂量和疗程。
