Soderstrom J, Murray L, Little M, Daly F F S
Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Emerg Med J. 2006 Nov;23(11):869-71. doi: 10.1136/emj.2006.034884.
A 29-year-old woman presents shortly after a massive overdose of carbamazepine controlled-release tablets. In anticipation of coma, she is electively intubated to safely enable gastrointestinal decontamination with nasogastric activated charcoal. She is admitted to the intensive care unit for ongoing supportive care, and further doses of activated charcoal are prescribed to enhance elimination of carbamazepine. Carbamazepine levels remain high and haemodialysis is carried out to further enhance elimination. Her coma resolves as levels fall, but clinical progress is complicated by anticholinergic delirium, ileus and bowel obstruction from charcoal concretions. She survives to medical discharge on day 12.
一名29岁女性在过量服用大量卡马西平控释片后不久就诊。鉴于可能出现昏迷，她被择期插管，以便安全地通过鼻胃管给予活性炭进行胃肠道去污。她被收入重症监护病房接受持续的支持治疗，并开具了进一步剂量的活性炭以促进卡马西平的清除。卡马西平水平仍然很高，于是进行了血液透析以进一步促进清除。随着药物水平下降，她的昏迷症状得到缓解，但临床进程因抗胆碱能谵妄、肠梗阻以及活性炭结块导致的肠梗阻而变得复杂。她在第12天康复出院。
