Türel Ermertcan Aylin, Temeltaş Gökhan, Deveci Artuner, Dinç Gönül, Güler H Bilge, Oztürkcan Serap
Department of Dermatology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
J Dermatol. 2006 Nov;33(11):772-8. doi: 10.1111/j.1346-8138.2006.00179.x.
Psoriasis can have a significant impact upon sexual function. The aim of this study was to investigate sexual function in females and males with psoriasis and to evaluate whether coexistent depression has an additional negative effect on sexual function in these patients. A total of 66 female subjects (39 with psoriasis and 27 healthy volunteers as a control group) and 70 male subjects (39 with psoriasis and 31 healthy volunteers as a control group) were enrolled in the study. A Psoriasis Area and Severity Index (PASI) was used to determine the severity of psoriasis for the patient groups. The Female Sexual Function Index (FSFI) was used to assess female sexual function and the International Index of Erectile Function (IIEF) was used to evaluate male sexual function. Quality of life was assessed with the Dermatology Life Quality Index (DLQI). The diagnosis of depression was made according to the Structured Clinical Interview for DSM-IV (SCID-I) interview and Hamilton Depression Rate Scale (HDRS) was used for grading depression. FSFI total score was found to be significantly decreased in female psoriatic patients without depression and psoriatic patients plus depression compared with healthy controls (24.09 +/- 5.33 vs. 24.25 +/- 4.52 vs. 28.12 +/- 3.48, respectively, p = 0.004). However, FSFI score was not significantly different between patients with psoriasis without depression and those with psoriasis plus depression (p > 0.05). IIEF total score was also found to be significantly decreased in male psoriasis without depression and psoriasis plus depression patients compared with healthy controls (54.21 +/- 13.07 vs. 52.0 +/- 14.73 vs. 61.69 +/- 9.49, respectively, p = 0.023). The difference in IIEF scores between patients with psoriasis without depression and in those with psoriasis plus depression were not statistically significant (p > 0.05). The results of the study demonstrated that patients with psoriasis, especially females have distinct sexual dysfunction compared with healthy controls, and coexistent depression has no additional negative effect on sexual dysfunction in our patients. Patients with psoriasis should be evaluated in terms of sexual function in order to provide a better quality of life.
银屑病可对性功能产生重大影响。本研究的目的是调查银屑病女性和男性的性功能，并评估并存的抑郁症是否会对这些患者的性功能产生额外的负面影响。共有66名女性受试者（39名银屑病患者和27名健康志愿者作为对照组）和70名男性受试者（39名银屑病患者和31名健康志愿者作为对照组）纳入本研究。银屑病面积和严重程度指数（PASI）用于确定患者组银屑病的严重程度。女性性功能指数（FSFI）用于评估女性性功能，国际勃起功能指数（IIEF）用于评估男性性功能。生活质量采用皮肤病生活质量指数（DLQI）进行评估。根据《精神疾病诊断与统计手册》第四版（DSM-IV）的结构化临床访谈进行抑郁症诊断，并使用汉密尔顿抑郁量表（HDRS）对抑郁症进行分级。发现无抑郁症的女性银屑病患者和合并抑郁症的银屑病患者的FSFI总分与健康对照组相比显著降低（分别为24.09±5.33、24.25±4.52和28.12±3.48，p = 0.004）。然而，无抑郁症的银屑病患者和合并抑郁症的银屑病患者之间的FSFI评分无显著差异（p > 0.05）。与健康对照组相比，无抑郁症的男性银屑病患者和合并抑郁症的银屑病患者的IIEF总分也显著降低（分别为54.21±13.07、52.0±14.73和61.69±9.49，p = 0.023）。无抑郁症的银屑病患者和合并抑郁症的银屑病患者之间的IIEF评分差异无统计学意义（p > 0.05）。研究结果表明，银屑病患者，尤其是女性，与健康对照组相比存在明显的性功能障碍，并存的抑郁症对我们的患者性功能无额外的负面影响。应对银屑病患者的性功能进行评估，以提供更好的生活质量。
