Busse Anja, Angermeyer Matthias C, Riedel-Heller Steffi G
Department of Psychiatry, University of Leipzig, Johannisallee 20, 04317 Leipzig, Germany.
Br J Psychiatry. 2006 Nov;189:399-404. doi: 10.1192/bjp.bp.105.014779.
Studies of conversion from mild cognitive impairment to dementia suggest a linear progression over time. Conversion rates during lifetime may extend to 80-90%.
This study examines the time-dependent evolution from mild cognitive impairment to dementia. Current assumptions regarding yearly and lifetime conversion rates are challenged.
A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing based on 6 years of observation.
Approximately 60-65% of people with mild cognitive impairment develop clinical dementia during their life. Progression from mild cognitive impairment to dementia appears to be time dependent, occurring primarily within the initial 18 months.
Further long-term studies are needed to examine the time-dependent evolution from mild cognitive impairment to dementia and to establish age-specific conversion rates during lifetime.
从轻度认知障碍转变为痴呆症的研究表明，随着时间推移呈线性进展。一生中的转化率可能高达80 - 90%。
本研究考察从轻度认知障碍到痴呆症的时间依赖性演变。对当前关于年度和终生转化率的假设提出质疑。
对1045名75岁及以上无痴呆症的社区样本个体进行了基于6年观察的神经心理学测试。
约60 - 65%的轻度认知障碍患者在其一生中会发展为临床痴呆症。从轻度认知障碍到痴呆症的进展似乎与时间有关，主要发生在最初的18个月内。
需要进一步开展长期研究，以考察从轻度认知障碍到痴呆症的时间依赖性演变，并确定一生中特定年龄的转化率。
