Häkkinen Jukka T, Hakama Matti, Shiri Rahman, Auvinen Anssi, Tammela Teuvo L J, Koskimäki Juha
Department of Urology, Tampere University Hospital, Teiskontie 35, FIN-33521 Tampere, Finland.
J Urol. 2006 Dec;176(6 Pt 1):2541-5; discussion 2545. doi: 10.1016/j.juro.2006.08.017.
We estimated the incidence and natural course of nocturia in an unselected Finnish male population.
A mail interview of a cohort of 3,143 randomly selected men 50 to 70 year old at study entry was done in Finland in 1994, 1999 and 2004. The questionnaire included questions on sociodemographic status, overall health and disease, urinary symptoms, sexual functioning and symptom bother. The overall response rate was 70% on the 1994 survey, 75% on the 1999 survey and 76% on the 2004 survey. A response to nocturia questions was obtained from 1,633 men at the 1994 to 1999 followup and from 1,618 at the 1999 to 2004 followup.
The overall prevalence of 1 or more nocturnal voidings was 56% at baseline and 74% 10 years later. The crude incidence rate for nocturia was 75 new cases per 1,000 men annually (95% CI 66 to 85) during the first 5-year followup period and 126/1,000 (95% CI 113 to 140) during the second period. The incidence of moderate or severe nocturia was 9/1,000 (95% CI 7 to 11) and 14/1,000 men (95% CI 12 to 17), respectively. Incidence and prevalence increased clearly with age but also by calendar time, which was most prominent for the mild nocturia incidence. The incidence of moderate to severe symptoms increased, especially in the oldest cohort (incidence density ratio 5.6 to 5.7/5 years).
Every year 10% more males older than 50 years start to void during the night. The incidence of mild nocturia increases, especially in men when they age from 50 to 60 years. In older men mild symptoms are more stable but the incidence of severe nocturia increases strongly after age 75 years.
我们评估了未经过筛选的芬兰男性人群中夜尿症的发病率及自然病程。
1994年、1999年和2004年在芬兰对一组3143名年龄在50至70岁之间、研究开始时随机选取的男性进行了邮寄问卷调查。问卷包括社会人口学状况、整体健康与疾病、泌尿系统症状、性功能及症状困扰等问题。1994年调查的总回复率为70%，1999年为75%，2004年为76%。在1994年至1999年的随访中，1633名男性回答了夜尿症相关问题；在1999年至2004年的随访中，1618名男性回答了相关问题。
基线时1次或以上夜间排尿的总体患病率为56%，10年后为74%。在第一个5年随访期，夜尿症的粗发病率为每1000名男性每年75例新发病例（95%可信区间66至85），第二个5年随访期为126/1000（95%可信区间113至140）。中度或重度夜尿症的发病率分别为9/1000（95%可信区间7至11）和14/1000名男性（95%可信区间12至17）。发病率和患病率随年龄增长而明显增加，但也随时间推移而增加，这在轻度夜尿症发病率方面最为显著。中度至重度症状的发病率增加，尤其是在年龄最大的队列中（发病率密度比为5.6至5.7/5年）。
50岁以上男性每年有10%以上开始出现夜间排尿。轻度夜尿症的发病率增加，尤其是在50至60岁的男性中。在老年男性中，轻度症状更稳定，但75岁以后重度夜尿症的发病率大幅增加。
