Shing Cecilia M, Peake Jonathan, Suzuki Katsuhiko, Okutsu Mitsuharu, Pereira Rosie, Stevenson Lesley, Jenkins David G, Coombes Jeff S
School of Human Movement Studies, The University of Queensland, St. Lucia, Queensland, Australia 4072.
J Appl Physiol (1985). 2007 Mar;102(3):1113-22. doi: 10.1152/japplphysiol.00553.2006. Epub 2006 Nov 9.
The aim of this study was to investigate the influence of low-dose bovine colostrum protein concentrate (CPC) supplementation on selected immune variables in cyclists. Twenty-nine highly trained male road cyclists completed an initial 40-km time trial (TT(40)) and were then randomly assigned to either a supplement (n = 14, 10 g bovine CPC/day) or placebo group (n = 15, 10 g whey protein concentrate/day). After 5 wk of supplementation, the cyclists completed a second TT(40). They then completed 5 consecutive days of high-intensity training (HIT) that included a TT(40), followed by a final TT(40) in the following week. Venous blood and saliva samples were collected immediately before and after each TT(40), and upper respiratory illness symptoms were recorded over the experimental period. Compared with the placebo group, bovine CPC supplementation significantly increased preexercise serum soluble TNF receptor 1 during the HIT period (bovine CPC = 882 +/- 233 pg/ml, placebo = 468 +/- 139 pg/ml; P = 0.039). Supplementation also suppressed the postexercise decrease in cytotoxic/suppressor T cells during the HIT period (bovine CPC = -1.0 +/- 2.7%, placebo = -9.2 +/- 2.8%; P = 0.017) and during the following week (bovine CPC = 1.4 +/- 2.9%, placebo = -8.2 +/- 2.8%; P = 0.004). Bovine CPC supplementation prevented a postexercise decrease in serum IgG(2) concentration at the end of the HIT period (bovine CPC = 4.8 +/- 6.8%, P = 0.88; placebo = -9.7 +/- 6.9%, P = 0.013). There was a trend toward reduced incidence of upper respiratory illness symptoms in the bovine CPC group (P = 0.055). In summary, low-dose bovine CPC supplementation modulates immune parameters during normal training and after an acute period of intense exercise, which may have contributed to the trend toward reduced upper respiratory illness in the bovine CPC group.
本研究旨在调查补充低剂量牛初乳浓缩蛋白（CPC）对自行车运动员某些免疫指标的影响。29名训练有素的男性公路自行车运动员完成了初始40公里计时赛（TT(40)），然后被随机分为补充剂组（n = 14，每日10克牛CPC）或安慰剂组（n = 15，每日10克乳清浓缩蛋白）。补充5周后，自行车运动员完成了第二次TT(40)。然后他们连续进行了5天的高强度训练（HIT），其中包括一次TT(40)，随后在接下来的一周进行了最后一次TT(40)。在每次TT(40)之前和之后立即采集静脉血和唾液样本，并在实验期间记录上呼吸道疾病症状。与安慰剂组相比，补充牛CPC在HIT期间显著增加了运动前血清可溶性TNF受体1（牛CPC = 882±233 pg/ml，安慰剂 = 468±139 pg/ml；P = 0.039）。补充剂还抑制了HIT期间（牛CPC = -1.0±2.7%，安慰剂 = -9.2±2.8%；P = 0.017）以及接下来一周（牛CPC = 1.4±2.9%，安慰剂 = -8.2±2.8%；P = 0.004）运动后细胞毒性/抑制性T细胞的减少。补充牛CPC可防止HIT期结束时运动后血清IgG(2)浓度下降（牛CPC = 4.8±6.8%，P = 0.88；安慰剂 = -9.7±6.9%，P = 0.013）。牛CPC组上呼吸道疾病症状的发生率有降低趋势（P = 0.055）。总之，低剂量牛CPC补充剂在正常训练期间和急性高强度运动后可调节免疫参数，这可能是牛CPC组上呼吸道疾病减少趋势的原因。
