Vazquez Alexei
The Simons Center for Systems Biology, Institute for Advanced Study, Einstein Dr, Princeton, NJ 08540, USA.
J Theor Biol. 2007 Mar 7;245(1):125-9. doi: 10.1016/j.jtbi.2006.09.018. Epub 2006 Sep 23.
Our chances to halt epidemic outbreaks rely on how accurately we represent the population structure underlying the disease spread. When analysing global epidemics this force us to consider metapopulation models taking into account intra- and inter-community interactions. Here I introduce and analyze a metapopulation model which accounts for several features observed in real outbreaks. First, I demonstrate that depending on the intra-community expected outbreak size and the fraction of social bridges the epidemic outbreaks die out or there is a finite probability to observe a global epidemics. Second, I show that the global scenario is characterized by resurgent epidemics, their number increasing with increasing the intra-community average distance between individuals. Finally, I present empirical data for the AIDS epidemics supporting the model predictions.
我们阻止疫情爆发的机会取决于我们对疾病传播背后的人口结构的准确呈现程度。在分析全球疫情时,这迫使我们考虑元种群模型,同时要考虑社区内部和社区之间的相互作用。在此,我介绍并分析了一个元种群模型,该模型考虑了实际疫情中观察到的几个特征。首先,我证明,根据社区内部预期的疫情规模和社会桥梁的比例,疫情爆发会逐渐平息,或者存在观察到全球疫情的有限概率。其次,我表明全球疫情的情况以疫情死灰复燃为特征,其数量随着社区内部个体平均距离的增加而增加。最后,我展示了支持该模型预测的艾滋病疫情的实证数据。