Rubin David T, Turner Jerrold R
Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Clin Gastroenterol Hepatol. 2006 Nov;4(11):1309-13. doi: 10.1016/j.cgh.2006.09.010.
Cancer prevention in inflammatory bowel disease depends on the detection of precancerous dysplasia during scheduled screening and surveillance colonoscopy, but the detection and diagnosis of dysplasia remain challenging. In this article, we review the risks of cancer and dysplasia in ulcerative colitis and the current prevention recommendations, and through a sample case, we demonstrate an approach that involves an active partnership between the gastroenterologist or surgeon and pathologist. We address the challenge of management of polypoid lesions and incorporate new information about degree of inflammation as an additional risk of neoplasia in these patients.
炎症性肠病的癌症预防依赖于在定期筛查和监测结肠镜检查期间对癌前发育异常的检测,但发育异常的检测和诊断仍然具有挑战性。在本文中,我们回顾了溃疡性结肠炎中癌症和发育异常的风险以及当前的预防建议,并通过一个病例,展示了一种胃肠病学家或外科医生与病理学家积极合作的方法。我们讨论了息肉样病变的管理挑战,并纳入了有关炎症程度的新信息,将其作为这些患者肿瘤形成的额外风险。