Ashburn Ann, Fazakarley Louise, Ballinger Claire, Pickering Ruth, McLellan Lindsay D, Fitton Carolyn
Rehabilitation Research Unit, School of Health Professions and Rehabilitation Sciences, University of Southampton, Level E, Centre Block, Mailpoint 886, Southampton General Hospital, Tremona Rd, Southampton SO16 6YD, UK.
J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):678-84. doi: 10.1136/jnnp.2006.099333. Epub 2006 Nov 21.
To evaluate the effectiveness of a personalised home programme of exercises and strategies for repeat fallers with Parkinson's disease (PD).
Patients with a confirmed diagnosis of idiopathic PD, independently mobile, living at home in the community, experiencing more than one fall in the previous 12 months and with intact gross cognitive function were invited to participate in this randomised controlled trial. Usual care was compared with a personalised 6 week, home based exercise and strategy programme. The primary outcomes were rates of falling at 8 weeks and 6 months. Whether participants had repeat fallen, nearly fallen or experienced injurious falls were also examined. Functional Reach, the Berg Balance Test, PD Self-assessment Scale and the Euro Quol were rated by a blinded assessor.
Participants were randomised to the exercise (n = 70) and control (n = 72) groups. There was a consistent trend towards lower fall rates in the exercise group at both 8 weeks and 6 months and lower rates of injurious falls needing medical attention at 6 months. Lower rates of repeat near falling were evident for the exercise group at 8 weeks (p = 0.004) and 6 months (p = 0.007). There was a positive effect of exercises at 6 months on Functional Reach (p = 0.009) and quality of life (p = 0.033). No significant differences were found on other secondary outcomes measures.
There was a trend towards a reduction in fall events and injurious falls with a positive effect of exercises on near falls and quality of life.
评估针对帕金森病(PD)反复跌倒患者的个性化家庭锻炼计划及策略的有效性。
邀请确诊为特发性PD、能够独立活动、居住在社区家中、在过去12个月内跌倒超过一次且总体认知功能完好的患者参与这项随机对照试验。将常规护理与为期6周的个性化家庭锻炼及策略计划进行比较。主要结局指标为8周和6个月时的跌倒发生率。还对参与者是否再次跌倒、险些跌倒或经历过致伤性跌倒进行了检查。由一名盲法评估者对功能性伸展、伯格平衡测试、PD自我评估量表和欧洲五维度健康量表进行评分。
参与者被随机分为锻炼组(n = 70)和对照组(n = 72)。锻炼组在8周和6个月时的跌倒率均有持续下降的趋势,在6个月时需要医疗关注的致伤性跌倒率也较低。锻炼组在8周(p = 0.004)和6个月(p = 0.007)时再次险些跌倒的发生率较低。锻炼在6个月时对功能性伸展(p = 0.009)和生活质量(p = 0.033)有积极影响。在其他次要结局指标上未发现显著差异。
跌倒事件和致伤性跌倒有减少的趋势,锻炼对险些跌倒和生活质量有积极影响。