Dias João Carlos Pinto
Centro de Pesquisas René Rachou, Fundação Oswaldo CruzBelo Horizonte, MG, Brasil.
Rev Soc Bras Med Trop. 2006 Jul-Aug;39(4):370-5. doi: 10.1590/s0037-86822006000400010.
Experimental evidence and field observations concerning the oral transmission of Trypanosoma cruzi to human beings and mammalian species are reviewed, confirming its unquestionable occurrence, mainly in the enzootic cycle of the parasite. Several types of foods and carriers of the flagellate have been involved in this transmission route, where the human cases are generally related to infected triatomines and/or natural reservoirs in the proximities of the event. The penetration points of the parasite (mouth, esophagus, stomach and intestinal mucosae) are reviewed, as well as the general anatomic and pathological processes, such as hemorrhagic phenomena, mesenteritis and interstitial hepatitis. In particular, different aspects of the biology and biochemistry of the parasite are analyzed, especially in terms of its epidemiology and the possibilities of the prevention of the oral transmission of Chagas' disease.
本文综述了关于克氏锥虫经口传播给人类和哺乳动物的实验证据及现场观察结果,证实了其确凿存在,主要发生在该寄生虫的动物疫源循环中。多种类型的食物及鞭毛虫载体参与了这一传播途径,在此传播途径中,人类感染病例通常与事件发生地附近受感染的锥蝽和/或天然宿主有关。文中回顾了寄生虫的侵入部位(口腔、食管、胃和肠黏膜),以及一般的解剖学和病理学过程,如出血现象、肠系膜炎症和间质性肝炎。特别分析了寄生虫生物学和生物化学的不同方面,尤其是其流行病学以及预防恰加斯病经口传播的可能性。