在感染持续时间不明的初治抗逆转录病毒治疗个体中进行HIV标准基因分型的临床效用。
Clinical utility of HIV standard genotyping among antiretroviral-naive individuals with unknown duration of infection.
作者信息
Smith Davey, Moini Niousha, Pesano Rick, Cachay Edward, Aiem Heidi, Lie Yolanda, Richman Douglas, Little Susan
机构信息
University of California San Diego, San Diego, CA 92103, USA.
出版信息
Clin Infect Dis. 2007 Feb 1;44(3):456-8. doi: 10.1086/510748. Epub 2006 Dec 28.
In clinical settings, we have found a high rate of human immunodeficiency virus (HIV) drug resistance among antiretroviral-naive patients for whom the duration of infection was unknown. These high rates were most likely the result of both transmitted resistance and informal antiretroviral use, and they suggest that routine resistance testing among antiretroviral-naive patients would be a cost-effective clinical practice.
在临床环境中，我们发现对于感染持续时间未知的初治抗逆转录病毒治疗患者，人类免疫缺陷病毒（HIV）耐药率很高。这些高耐药率很可能是传播性耐药和非正规抗逆转录病毒药物使用共同导致的结果，这表明在初治抗逆转录病毒治疗患者中进行常规耐药检测将是一种具有成本效益的临床实践。
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