Backé E, Schwarting R, Gerdes J, Ernst M, Stein H
Institut für Pathologie, Klinikum Steglitz, Berlin, Germany.
J Clin Pathol. 1991 Nov;44(11):936-45. doi: 10.1136/jcp.44.11.936.
A new monoclonal antibody Ber-MAC3 is reported. It recognises a formol sensitive epitope of a not yet clustered monocyte/macrophage specific 140 kilodalton glycoprotein that is expressed on the cell surface and in the cytoplasm. In 30 cases of acute and chronic leukaemia, Ber-MAC3 staining was restricted to 15 myeloid leukaemias of M4 and M5 types. The tumour cells of two cases of true histiocytic malignancies were Ber-MAC3 positive, whereas those of all 280 malignancies of lymphocytic origin were negative. The latter included 52 cases of Hodgkin's disease and 41 cases of Ki-1 positive anaplastic large cell lymphomas which had previously been classified as true histiocytic lymphomas. Ber-MAC3 therefore seems to be of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and seems to be suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin.
据报道，一种新的单克隆抗体Ber-MAC3被发现。它识别一种尚未聚集的单核细胞/巨噬细胞特异性140千道尔顿糖蛋白的甲醛敏感表位，该糖蛋白在细胞表面和细胞质中表达。在30例急性和慢性白血病中，Ber-MAC3染色仅限于15例M4和M5型髓系白血病。2例真性组织细胞恶性肿瘤的肿瘤细胞Ber-MAC3呈阳性，而所有280例淋巴细胞源性恶性肿瘤的肿瘤细胞均为阴性。后者包括52例霍奇金病和41例Ki-1阳性间变性大细胞淋巴瘤，这些病例以前被归类为真性组织细胞淋巴瘤。因此，Ber-MAC3似乎对于在特定分化阶段选择性识别单核细胞和巨噬细胞具有重要价值，似乎适用于诊断髓单核细胞或单核细胞白血病以及真性组织细胞源性肿瘤。
