Nayak R, Sudha P
Dept. of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Mangalore.
Indian J Dent Res. 2006 Oct-Dec;17(4):155-60. doi: 10.4103/0970-9290.29871.
To compare pain responses of children during local anaesthetic infiltration at bilateral buccal sites prepared with topical application of EMLA 5% cream, benzocaine 18% gel or lignocaine 5% ointment and also to find out the rapidity of onset of action of these agents.
60 healthy children aged 6 to 12 years old, received bilateral buccal infiltration following application of topical anaesthetic agents applied in a double blind design. Pain responses were compared based on subject self report using visual analogue scale (VAS) and operator assessment using Sound -Eye -Motor (SEM) scale.
Benzocaine gel had the rapidest onset of action. EMLA 5% cream proved to be superior in pain reduction compared to benzocaine and lignocaine. Taste acceptance was better with benzocaine gel. Further studies are required for EMLA cream with an improved formulation more suitable for mucosal application before its routine use in dentistry.
比较在双侧颊部局部麻醉浸润时，使用复方利多卡因乳膏（EMLA）5%、苯佐卡因18%凝胶或利多卡因5%软膏进行局部应用预处理后儿童的疼痛反应，并找出这些药物的起效速度。
60名6至12岁的健康儿童，采用双盲设计在应用局部麻醉剂后接受双侧颊部浸润。基于受试者使用视觉模拟量表（VAS）的自我报告以及操作者使用视听运动（SEM）量表的评估来比较疼痛反应。
苯佐卡因凝胶起效最快。与苯佐卡因和利多卡因相比，复方利多卡因乳膏5%在减轻疼痛方面表现更优。苯佐卡因凝胶的口味接受度更好。在复方利多卡因乳膏常规用于牙科之前，需要对更适合黏膜应用的改良配方进行进一步研究。
