Pereira Luísa, Gonçalves João, Franco-Duarte Ricardo, Silva Júlia, Rocha Tiago, Arnold Christiane, Richards Martin, Macaulay Vincent
Instituto de Patologia e Imunologia Molecular da Universidade do Porto, (IPATIMUP), Porto, Portugal.
Mol Biol Evol. 2007 Mar;24(3):868-74. doi: 10.1093/molbev/msm004. Epub 2007 Jan 11.
The first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.
对20例弱精子症患者的首个完整线粒体DNA（mtDNA）序列（约16,569 bp），以及与23例畸形精子症患者的23个新的完整mtDNA序列进行比较后，证实这些个体之间不存在特定多态性或特定线粒体谱系的共享。这有力地反驳了mtDNA在男性生育中起主要作用这一已被认可的观点，该观点曾得到基于高变区I筛选的单倍群关联研究的支持。因此，对于母系驱动的选择作用于男性生殖成功这一假说必须谨慎对待。
