头颈部放疗的口腔并发症
Oral complications of radiotherapy in the head and neck.
作者信息
Jham Bruno Correia, da Silva Freire Addah Regina
机构信息
Faculdade de Odontologia, Universidade Federal de Minas Gerais, Brazil.
出版信息
Braz J Otorhinolaryngol. 2006 Sep-Oct;72(5):704-8. doi: 10.1016/s1808-8694(15)31029-6.
Abstract
UNLABELLED
Radiotherapy is a treatment modality largely used for head and neck malignancies. However, high doses of radiation in large areas, including the oral cavity, maxilla, mandible and salivary glands may result in several undesired reactions. Mucositis, candidosis, disgeusia, radiation caries, osteoradionecrosis, soft tissue necrosis and xerostomia are some of radiotherapys complications.
AIM
The aim of this study is to briefly review the side effects that may be seen in the oral cavity during or after radiotherapy treatment in the head and neck region. BASIC METHOD USED: Review of relevant literature.
STUDY DESIGN
Literature review.
RESULTS
Radiotherapy is still associated with several side effects, significantly affecting patients quality of life.
CONCLUSIONS
A multidisciplinary treatment, including physicians, dentists, speech therapists, nutritionists, and psychologists, is the best alternative to minimize, or even prevent such reactions.
摘要
未标注
放射疗法是一种主要用于治疗头颈部恶性肿瘤的治疗方式。然而，在大面积区域，包括口腔、上颌骨、下颌骨和唾液腺进行高剂量放疗可能会导致多种不良反应。口腔黏膜炎、念珠菌病、味觉障碍、放射性龋齿、放射性骨坏死、软组织坏死和口干症是放疗的一些并发症。
目的
本研究的目的是简要回顾头颈部放疗期间或放疗后口腔中可能出现的副作用。使用的基本方法：回顾相关文献。
研究设计
文献综述。
结果
放疗仍然会产生多种副作用，严重影响患者的生活质量。
结论
多学科治疗，包括医生、牙医、言语治疗师、营养师和心理学家，是将此类反应降至最低甚至预防的最佳选择。
相似文献
1
Oral complications of radiotherapy in the head and neck.头颈部放疗的口腔并发症
Braz J Otorhinolaryngol. 2006 Sep-Oct;72(5):704-8. doi: 10.1016/s1808-8694(15)31029-6.
2
Oral sequelae of head and neck radiotherapy.头颈部放疗的口腔后遗症
Crit Rev Oral Biol Med. 2003;14(3):199-212. doi: 10.1177/154411130301400305.
3
Prevention and treatment of the consequences of head and neck radiotherapy.头颈部放射治疗后果的预防与治疗。
Crit Rev Oral Biol Med. 2003;14(3):213-25. doi: 10.1177/154411130301400306.
4
Radiation therapy and oral care.放射治疗与口腔护理。
Dent Today. 2005 Mar;24(3):66-8, 70-1; quiz 71, 61.
5
Oral complications in radiation therapy.放射治疗中的口腔并发症。
Gen Dent. 2003 Nov-Dec;51(6):552-60; quiz 561.
6
Dental complications of head and neck radiotherapy: Part 1.头颈部放疗的牙科并发症：第1部分。
Aust Dent J. 2001 Jun;46(2):88-94. doi: 10.1111/j.1834-7819.2001.tb00562.x.
7
The head and neck radiotherapy patient: Part 2--Management of oral complications.头颈部放疗患者：第2部分——口腔并发症的管理
Compendium. 1994 Apr;15(4):442, 444, 446-52 passim; quiz 458.
8
Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients.头颈部放疗的口腔不良反应：文献回顾及对放疗患者临床口腔护理指南的建议。
J Appl Oral Sci. 2011 Oct;19(5):448-54. doi: 10.1590/s1678-77572011000500003.
9
The oral management of patients who have received radiotherapy to the head and neck region.头颈部接受放射治疗的患者的口腔管理。
Br Dent J. 2013 Apr;214(8):387-93. doi: 10.1038/sj.bdj.2013.380.
10
Dental complications of head and neck radiotherapy: Part 2.头颈部放疗的牙科并发症：第2部分。
Aust Dent J. 2001 Sep;46(3):174-82. doi: 10.1111/j.1834-7819.2001.tb00278.x.
引用本文的文献
1
Oropharyngeal candidiasis during radiotherapy for head and neck cancer: an observational study on prevalence, pain, and risk factors.头颈部癌放疗期间的口咽念珠菌病：一项关于患病率、疼痛及危险因素的观察性研究
Eur Arch Otorhinolaryngol. 2025 Jul 12. doi: 10.1007/s00405-025-09548-w.
2
Oral adverse effects of head and neck radiotherapy with/without chemotherapy in a southern Brazil hospital.巴西南部一家医院中头颈部放疗联合或不联合化疗的口腔不良反应
Braz Oral Res. 2025 Mar 31;39:e008. doi: 10.1590/1807-3107bor-2025.vol39.008. eCollection 2025.
3
Establishment of an Osteoradionecrosis Model and its Mechanism Via Single Ionizing Radiation Exposure.单次电离辐射暴露致放射性骨坏死模型的建立及其机制
Int Dent J. 2025 Jun;75(3):1672-1682. doi: 10.1016/j.identj.2025.03.006. Epub 2025 Mar 29.
4
Characterization of irradiated mucosa using confocal laser endomicroscopy in the upper aerodigestive tract.使用共聚焦激光内镜对上下呼吸道消化道受照射黏膜的特征分析
Eur Arch Otorhinolaryngol. 2025 May;282(5):2507-2514. doi: 10.1007/s00405-025-09318-8. Epub 2025 Mar 21.
5
Radiomorphometric indices for measuring mandibular bone quality in oncologic patients.用于测量肿瘤患者下颌骨质量的放射形态计量学指标。
Oral Radiol. 2025 Jan 20. doi: 10.1007/s11282-025-00803-8.
6
Advances in hybridized nanoarchitectures for improved oro-dental health.用于改善口腔健康的杂交纳米结构的进展。
J Nanobiotechnology. 2024 Aug 7;22(1):469. doi: 10.1186/s12951-024-02680-5.
7
In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma.体内建模概括了儿童髓母细胞瘤的放射治疗过程和晚期效应特征。
Neurooncol Adv. 2024 Jun 6;6(1):vdae091. doi: 10.1093/noajnl/vdae091. eCollection 2024 Jan-Dec.
8
Assessment of multispecies biofilm growth on root canal dentin under different radiation therapy regimens.评估不同放射治疗方案下根管牙本质上多菌种生物膜的生长情况。
Clin Oral Investig. 2024 May 18;28(6):324. doi: 10.1007/s00784-024-05719-x.
9
Chemotherapy increases the prevalence of radiotherapy-related trismus in head and neck cancer patients: A systematic review and meta-analysis.化疗增加头颈部癌患者放疗相关牙关紧闭的发生率：一项系统评价和荟萃分析。
J Clin Exp Dent. 2024 Apr 1;16(4):e503-e515. doi: 10.4317/jced.61385. eCollection 2024 Apr.
10
Photobiomodulation therapy in the treatment of radiotherapy-related trismus of the head and neck.光生物调节疗法治疗头颈部放疗相关的张口困难。
Lasers Med Sci. 2023 Nov 8;38(1):259. doi: 10.1007/s10103-023-03920-0.
本文引用的文献
1
Candida oral colonization and infection in Brazilian patients undergoing head and neck radiotherapy: a pilot study.巴西头颈部放疗患者口腔念珠菌定植与感染的初步研究。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103(3):355-8. doi: 10.1016/j.tripleo.2006.02.005. Epub 2006 Apr 21.
2
A randomized phase III prospective trial of bethanechol to prevent radiotherapy-induced salivary gland damage in patients with head and neck cancer.一项关于使用氨甲酰甲胆碱预防头颈癌患者放疗引起唾液腺损伤的随机III期前瞻性试验。
Oral Oncol. 2007 Feb;43(2):137-42. doi: 10.1016/j.oraloncology.2006.01.013. Epub 2006 Jun 23.
3
A prospective study of salivary gland function in patients undergoing radiotherapy for squamous cell carcinoma of the oropharynx.一项针对口咽鳞状细胞癌放疗患者唾液腺功能的前瞻性研究。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):173-89. doi: 10.1016/s1079-2104(03)00473-6.
4
An update of the etiology and management of xerostomia.口干症的病因及治疗进展
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jan;97(1):28-46. doi: 10.1016/j.tripleo.2003.07.010.
5
Oral and dental management related to radiation therapy for head and neck cancer.与头颈癌放射治疗相关的口腔和牙科处理
J Can Dent Assoc. 2003 Oct;69(9):585-90.
6
Salivary gland function and xerostomia in southern Chinese following radiotherapy for nasopharyngeal carcinoma.中国南方鼻咽癌患者放疗后的唾液腺功能与口干症
Clin Oral Investig. 2003 Dec;7(4):230-4. doi: 10.1007/s00784-003-0215-6. Epub 2003 Aug 29.
7
Long-term oral Candida colonization, mucositis and salivary function after head and neck radiotherapy.头颈部放疗后的长期口腔念珠菌定植、黏膜炎和唾液功能
Support Care Cancer. 2003 Nov;11(11):717-21. doi: 10.1007/s00520-003-0506-0. Epub 2003 Aug 9.
8
Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.目前针对口干症以及与癌症治疗相关的唾液腺功能减退的疗法。
Support Care Cancer. 2003 Apr;11(4):226-31. doi: 10.1007/s00520-002-0409-5. Epub 2002 Oct 22.
9
Oral microbiota associated with hyposalivation of different origins.与不同来源的唾液分泌减少相关的口腔微生物群
Oral Microbiol Immunol. 2003 Feb;18(1):1-8. doi: 10.1034/j.1399-302x.2003.180101.x.
10
Salivary gland hypofunction in patients with advanced cancer.晚期癌症患者的唾液腺功能减退
Oral Oncol. 2002 Oct;38(7):680-5. doi: 10.1016/s1368-8375(01)00133-6.
Zotero 插件