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头颈部放疗的口腔并发症

Oral complications of radiotherapy in the head and neck.

作者信息

Jham Bruno Correia, da Silva Freire Addah Regina

机构信息

Faculdade de Odontologia, Universidade Federal de Minas Gerais, Brazil.

出版信息

Braz J Otorhinolaryngol. 2006 Sep-Oct;72(5):704-8. doi: 10.1016/s1808-8694(15)31029-6.

DOI:10.1016/s1808-8694(15)31029-6
PMID:17221065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9443542/
Abstract

UNLABELLED

Radiotherapy is a treatment modality largely used for head and neck malignancies. However, high doses of radiation in large areas, including the oral cavity, maxilla, mandible and salivary glands may result in several undesired reactions. Mucositis, candidosis, disgeusia, radiation caries, osteoradionecrosis, soft tissue necrosis and xerostomia are some of radiotherapys complications.

AIM

The aim of this study is to briefly review the side effects that may be seen in the oral cavity during or after radiotherapy treatment in the head and neck region. BASIC METHOD USED: Review of relevant literature.

STUDY DESIGN

Literature review.

RESULTS

Radiotherapy is still associated with several side effects, significantly affecting patients quality of life.

CONCLUSIONS

A multidisciplinary treatment, including physicians, dentists, speech therapists, nutritionists, and psychologists, is the best alternative to minimize, or even prevent such reactions.

摘要

未标注

放射疗法是一种主要用于治疗头颈部恶性肿瘤的治疗方式。然而,在大面积区域,包括口腔、上颌骨、下颌骨和唾液腺进行高剂量放疗可能会导致多种不良反应。口腔黏膜炎、念珠菌病、味觉障碍、放射性龋齿、放射性骨坏死、软组织坏死和口干症是放疗的一些并发症。

目的

本研究的目的是简要回顾头颈部放疗期间或放疗后口腔中可能出现的副作用。使用的基本方法:回顾相关文献。

研究设计

文献综述。

结果

放疗仍然会产生多种副作用,严重影响患者的生活质量。

结论

多学科治疗,包括医生、牙医、言语治疗师、营养师和心理学家,是将此类反应降至最低甚至预防的最佳选择。

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Oral complications of radiotherapy in the head and neck.头颈部放疗的口腔并发症
Braz J Otorhinolaryngol. 2006 Sep-Oct;72(5):704-8. doi: 10.1016/s1808-8694(15)31029-6.
2
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本文引用的文献

1
Candida oral colonization and infection in Brazilian patients undergoing head and neck radiotherapy: a pilot study.巴西头颈部放疗患者口腔念珠菌定植与感染的初步研究。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103(3):355-8. doi: 10.1016/j.tripleo.2006.02.005. Epub 2006 Apr 21.
2
A randomized phase III prospective trial of bethanechol to prevent radiotherapy-induced salivary gland damage in patients with head and neck cancer.一项关于使用氨甲酰甲胆碱预防头颈癌患者放疗引起唾液腺损伤的随机III期前瞻性试验。
Oral Oncol. 2007 Feb;43(2):137-42. doi: 10.1016/j.oraloncology.2006.01.013. Epub 2006 Jun 23.
3
A prospective study of salivary gland function in patients undergoing radiotherapy for squamous cell carcinoma of the oropharynx.一项针对口咽鳞状细胞癌放疗患者唾液腺功能的前瞻性研究。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):173-89. doi: 10.1016/s1079-2104(03)00473-6.
4
An update of the etiology and management of xerostomia.口干症的病因及治疗进展
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jan;97(1):28-46. doi: 10.1016/j.tripleo.2003.07.010.
5
Oral and dental management related to radiation therapy for head and neck cancer.与头颈癌放射治疗相关的口腔和牙科处理
J Can Dent Assoc. 2003 Oct;69(9):585-90.
6
Salivary gland function and xerostomia in southern Chinese following radiotherapy for nasopharyngeal carcinoma.中国南方鼻咽癌患者放疗后的唾液腺功能与口干症
Clin Oral Investig. 2003 Dec;7(4):230-4. doi: 10.1007/s00784-003-0215-6. Epub 2003 Aug 29.
7
Long-term oral Candida colonization, mucositis and salivary function after head and neck radiotherapy.头颈部放疗后的长期口腔念珠菌定植、黏膜炎和唾液功能
Support Care Cancer. 2003 Nov;11(11):717-21. doi: 10.1007/s00520-003-0506-0. Epub 2003 Aug 9.
8
Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.目前针对口干症以及与癌症治疗相关的唾液腺功能减退的疗法。
Support Care Cancer. 2003 Apr;11(4):226-31. doi: 10.1007/s00520-002-0409-5. Epub 2002 Oct 22.
9
Oral microbiota associated with hyposalivation of different origins.与不同来源的唾液分泌减少相关的口腔微生物群
Oral Microbiol Immunol. 2003 Feb;18(1):1-8. doi: 10.1034/j.1399-302x.2003.180101.x.
10
Salivary gland hypofunction in patients with advanced cancer.晚期癌症患者的唾液腺功能减退
Oral Oncol. 2002 Oct;38(7):680-5. doi: 10.1016/s1368-8375(01)00133-6.