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Schizophrenia and bipolar disorder are neurodevelopmental disorders with significant genetic vulnerabilities. Several trophic genes and/or proteins have been implicated in the causation for both disorders.2. We hypothesized that these genes and/or proteins may impact neuronal growth in both disorders.3. Hippocampal tissue sections from CA1 area of schizophrenic, bipolar, depressed, and controls subjects, matched for age, sex, PMI, drug exposure, and brain pH were prepared for cell size determination using the Stanley Medical Research Foundation postmortem brain collection.4. Quantification of hippocampal CA1 pyramidal neuron size showed a significant 12% reduction in cell size (p < 0.05) in bipolar subjects vs. controls. There were nonsignificant trends for reduction in cell size in both schizophrenic and depressed subjects vs. controls.5. These results indicate for the first time that pyramidal cell atrophy is present in hippocampus of subjects with bipolar disorder.

精神分裂症和双相情感障碍是具有显著遗传易感性的神经发育障碍。几种营养基因和/或蛋白质与这两种疾病的病因有关。
我们假设这些基因和/或蛋白质可能会影响这两种疾病中的神经元生长。
使用斯坦利医学研究基金会的尸检脑库，制备了来自精神分裂症、双相情感障碍、抑郁症患者以及年龄、性别、PMI、药物暴露和脑pH值相匹配的对照组受试者CA1区的海马组织切片，用于测定细胞大小。
海马CA1区锥体神经元大小的量化显示，与对照组相比，双相情感障碍患者的细胞大小显著减少了12%（p < 0.05）。精神分裂症患者和抑郁症患者与对照组相比，细胞大小减少的趋势不显著。
这些结果首次表明，双相情感障碍患者的海马中存在锥体细胞萎缩。

Schizophrenia and bipolar disorder are neurodevelopmental disorders with significant genetic vulnerabilities. Several trophic genes and/or proteins have been implicated in the causation for both disorders.2. We hypothesized that these genes and/or proteins may impact neuronal growth in both disorders.3. Hippocampal tissue sections from CA1 area of schizophrenic, bipolar, depressed, and controls subjects, matched for age, sex, PMI, drug exposure, and brain pH were prepared for cell size determination using the Stanley Medical Research Foundation postmortem brain collection.4. Quantification of hippocampal CA1 pyramidal neuron size showed a significant 12% reduction in cell size (p < 0.05) in bipolar subjects vs. controls. There were nonsignificant trends for reduction in cell size in both schizophrenic and depressed subjects vs. controls.5. These results indicate for the first time that pyramidal cell atrophy is present in hippocampus of subjects with bipolar disorder.

精神分裂症和双相情感障碍是具有显著遗传易感性的神经发育障碍。几种营养基因和/或蛋白质与这两种疾病的病因有关。
我们假设这些基因和/或蛋白质可能会影响这两种疾病中的神经元生长。
使用斯坦利医学研究基金会的尸检脑库，制备了来自精神分裂症、双相情感障碍、抑郁症患者以及年龄、性别、PMI、药物暴露和脑pH值相匹配的对照组受试者CA1区的海马组织切片，用于测定细胞大小。
海马CA1区锥体神经元大小的量化显示，与对照组相比，双相情感障碍患者的细胞大小显著减少了12%（p < 0.05）。精神分裂症患者和抑郁症患者与对照组相比，细胞大小减少的趋势不显著。
这些结果首次表明，双相情感障碍患者的海马中存在锥体细胞萎缩。

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