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本文引用的文献

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The capsule polysaccharide structure and biogenesis for non-O1 Vibrio cholerae NRT36S: genes are embedded in the LPS region.非O1群霍乱弧菌NRT36S的荚膜多糖结构与生物合成：相关基因嵌入脂多糖区域。
BMC Microbiol. 2007 Mar 15;7:20. doi: 10.1186/1471-2180-7-20.
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GISMO--gene identification using a support vector machine for ORF classification.GISMO——使用支持向量机进行开放阅读框分类的基因识别方法
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Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system.非O1、非O139型霍乱弧菌的基因组特征揭示了III型分泌系统的相关基因。
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Versatile and open software for comparing large genomes.用于比较大型基因组的通用且开放的软件。
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Comparative genome analysis of Vibrio vulnificus, a marine pathogen.创伤弧菌的比较基因组分析，一种海洋病原体。
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Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae.副溶血性弧菌的基因组序列：一种与霍乱弧菌不同的致病机制。
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Characterization of a novel Vibrio pathogenicity island (VPI-2) encoding neuraminidase (nanH) among toxigenic Vibrio cholerae isolates.产毒霍乱弧菌分离株中一个编码神经氨酸酶（nanH）的新型霍乱弧菌致病岛（VPI-2）的特性分析。
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Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona.与肠炎沙门氏菌鼠伤寒血清型DT104多药耐药区域相关的一个43千碱基基因组岛的完整核苷酸序列及其在噬菌体类型DT120和阿贡纳血清型中的鉴定。
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非O1群霍乱弧菌NRT36S的基因组显示出存在与O1群霍乱弧菌不同的致病机制。

The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from those of O1 Vibrio cholerae.

作者信息

Chen Yuansha, Johnson Judith A, Pusch Gordon D, Morris J Glenn, Stine O Colin

机构信息

University of Maryland, Howard Hall 585, 660 W. Redwood Street, Baltimore, MD 21201, USA.

出版信息

Infect Immun. 2007 May;75(5):2645-7. doi: 10.1128/IAI.01317-06. Epub 2007 Feb 5.

DOI:10.1128/IAI.01317-06
PMID:17283087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1865779/
Abstract

Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.

摘要

霍乱弧菌NRT36S是一种不产生霍乱毒素的非O1菌株，可使志愿者出现腹泻症状。对NRT36S的基因组进行了测序，以创建一个包含174个重叠群加上超级整合子区域的草图。我们对该基因组草图的分析揭示了几个推定的毒素基因和定植因子。除了证实不可凝集热稳定毒素的存在外，我们还鉴定出了一个三型分泌系统、一种推定外毒素、两种不同的RTX毒素以及四种菌毛系统的基因。