Korzyukov Oleg, Pflieger Mark E, Wagner Michael, Bowyer Susan M, Rosburg T, Sundaresan Karthik, Elger Christian Erich, Boutros Nashaat N
Department of Psychiatry, Wayne State University, 2751 E. Jefferson, Suite 304, Detroit, MI 48207, USA.
Neuroimage. 2007 Apr 1;35(2):814-26. doi: 10.1016/j.neuroimage.2006.12.011. Epub 2006 Dec 19.
Clarification of the cortical mechanisms underlying auditory sensory gating may advance our understanding of brain dysfunctions associated with schizophrenia. To this end, data from nine epilepsy patients who participated in an auditory paired-click paradigm during pre-surgical evaluation and had grids of electrodes covering temporal and frontal lobe were analyzed. A distributed source localization approach was applied to the intracranial P50 response and the Gating Difference Wave obtained by subtracting the response to the second stimuli from the response to the first stimuli. Source reconstruction of the P50 showed that the main generators of the response were localized in the temporal lobes. The analysis also suggested that the maximum neuronal activity contributing to the amplitude reduction in the P50 time range (phenomenon of auditory sensory gating) is localized at the frontal lobe. Present findings suggest that while the temporal lobe is the main generator of the P50 component, the frontal lobe seems to be a substantial contributor to the process of sensory gating as observed from scalp recordings.
阐明听觉感觉门控背后的皮质机制可能会增进我们对与精神分裂症相关的脑功能障碍的理解。为此，分析了九名癫痫患者的数据，这些患者在术前评估期间参与了听觉双点击范式，并且其电极网格覆盖了颞叶和额叶。将一种分布式源定位方法应用于颅内P50反应以及通过从对第一个刺激的反应中减去对第二个刺激的反应而获得的门控差异波。P50的源重建表明，反应的主要发生器位于颞叶。分析还表明，导致P50时间范围内振幅降低（听觉感觉门控现象）的最大神经元活动位于额叶。目前的研究结果表明，虽然颞叶是P50成分的主要发生器，但从头皮记录观察到，额叶似乎是感觉门控过程的重要贡献者。
