Karaçal Naci, Cobanoğlu Umit, Ambarcioğlu Omer, Kutlu Necmettin
Department of Plastic and Reconstructive Surgery, Karadeniz Technical University, Trabzon, Turkey.
J Plast Reconstr Aesthet Surg. 2007;60(3):300-3. doi: 10.1016/j.bjps.2006.03.051. Epub 2006 Jun 9.
Autologous fat transplantation for filling defects or augmenting tissue is a common procedure but may have unreliable results. While fibrin glues lead to increased proliferation of fibroblasts and local accumulation of vascular endothelial growth factor, which enhances the neovascularisation, in this study the efficacy of fibrin glues on fat graft survival was investigated. Inguinal fat pads from Sprague-Dawley rats were harvested and same volumes of autogenous fat grafts were implanted into the separate pockets with the aid of fibrin glue (Group 1) and saline solution (Group 2). All the fat grafts were harvested, washed, blotted dry, and volumetrically measured with the same method used peroperatively at 6 months after implantation. Mean graft survival values for Group 1 were compared with Group 2 and histopathological evaluation of the grafts was also made. There was a significantly higher survival rate of the grafts in Group 1 than control group (79+/-4% and 55+/-6%, respectively). Histopathological examination of the grafts demonstrated evident increase in neovascularisation of the fat grafts in the experimental group. The authors conclude that the fibrin glue significantly diminishes the fat graft resorption and further well-controlled studies are required before using fibrin glues for clinical purposes.
自体脂肪移植用于填充缺损或增加组织是一种常见的手术，但结果可能不可靠。虽然纤维蛋白胶可导致成纤维细胞增殖增加和血管内皮生长因子局部积聚，从而增强新血管形成，但在本研究中，对纤维蛋白胶对脂肪移植存活的疗效进行了研究。从Sprague-Dawley大鼠获取腹股沟脂肪垫，并将相同体积的自体脂肪移植借助纤维蛋白胶植入单独的腔隙中（第1组），以及借助盐溶液植入单独的腔隙中（第2组）。在植入后6个月，所有脂肪移植均被取出、清洗、吸干，并采用与手术时相同的方法进行体积测量。将第1组的平均移植存活值与第2组进行比较，并对移植组织进行组织病理学评估。第1组移植的存活率显著高于对照组（分别为79±4%和55±6%）。移植组织的组织病理学检查显示，实验组脂肪移植的新血管形成明显增加。作者得出结论，纤维蛋白胶可显著减少脂肪移植吸收，在将纤维蛋白胶用于临床之前，还需要进一步进行严格控制的研究。
