经输血传播的 T 细胞淋巴瘤患者的戊型肝炎病毒持续感染。

Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma.

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.

出版信息

Hepatol Res. 2007 Feb;37(2):113-20. doi: 10.1111/j.1872-034X.2007.00024.x.

DOI:10.1111/j.1872-034X.2007.00024.x

PMID:17300706

Abstract

AIM

With advent of reverse-transcription (RT)/polymerase chain reaction (PCR) for detection of the hepatitis E viral genome, we carried out retrospective examinations.

METHODS

Serum samples collected from 68 patients diagnosed as viral hepatitis with unknown etiology were tested for viral markers of hepatitis virus.

RESULTS

Two of them were found positive for hepatitis E viral RNA. While the clinical course of one patient (patient 1) was typical as acute hepatitis E, another patient (patient 2) was persistently infected with HEV. Patient 2 was infected with the virus via blood transfusion during chemotherapy against T-cell lymphoma. The entire viral genome from the donor was identical with that from the serum of patient 2 obtained on day 170 after the transfusion of the implicated red blood cell (RBC) product, confirming the transmission of HEV by transfusion. The patient remained negative for anti-HEV antibodies for the follow-up period of six months, probably due to immune suppression by lymphoma and chemotherapy.

CONCLUSION

We report here an unusual case of long-term HEV infection in a patient with T-cell lymphoma. Persistent infection with HEV was probably due to the absence of anti-HEV antibodies, which was caused by lymphoma and chemotherapy.

摘要

目的

随着逆转录（RT）/聚合酶链反应（PCR）检测庚型肝炎病毒基因组的出现，我们进行了回顾性检查。

方法

对 68 例病因不明的病毒性肝炎患者的血清样本进行了肝炎病毒的病毒标志物检测。

结果

其中 2 例血清庚型肝炎病毒 RNA 阳性。其中 1 例（患者 1）的临床过程典型为急性庚型肝炎，另 1 例（患者 2）则持续感染庚型肝炎病毒。患者 2 在接受 T 细胞淋巴瘤化疗期间因输血而感染该病毒。供体的整个病毒基因组与输血后 170 天患者 2 血清中的病毒完全相同，证实了输血传播庚型肝炎病毒。在接下来的 6 个月的随访期间，患者仍未检测到抗庚型肝炎病毒抗体，可能是由于淋巴瘤和化疗引起的免疫抑制。