Zaratiegui Mikel, Irvine Danielle V, Martienssen Robert A
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Cell. 2007 Feb 23;128(4):763-76. doi: 10.1016/j.cell.2007.02.016.
Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is discussed, as well as parallels with RNA silencing in imprinting, paramutation, polycomb silencing, and X inactivation. Interactions with regulatory sequences may well occur, but at the RNA rather than at the DNA level.
长期以来，人们一直认为非编码RNA通过与调控区域的序列特异性相互作用来控制基因表达。在此，我们综述了非编码RNA在异染色质沉默、转座元件（TE）沉默、减数分裂中未配对DNA以及发育过程中切除的DNA方面的作用。我们还讨论了RNA干扰和其他机制在共转录加工中的作用，以及与印记、副突变、多梳蛋白沉默和X染色体失活中的RNA沉默的相似之处。与调控序列的相互作用很可能发生，但发生在RNA而非DNA水平上。
