Mc Clean Conor M, Mc Laughlin Jim, Burke George, Murphy Marie H, Trinick Tom, Duly Ellie, Davison Gareth W
Sport and Exercise Sciences Research Institute, School of Sports Studies, University of Ulster, Shore Road, Newtownabbey, County Antrim, BT37 OQB, UK.
Eur J Appl Physiol. 2007 May;100(2):225-34. doi: 10.1007/s00421-007-0422-y. Epub 2007 Feb 24.
Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 +/- 2.5 years, VO2 max 58.5 +/- 7.1 ml kg(-1) min(-1)) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60% max HR) exercise. PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemical markers were measured. PWV increased at 1 h (6.49 +/- 2.1 m s(-1)), 2 h (6.94 +/- 2.4 m s(-1)), 3 h (7.25 +/- 2.1 m s(-1)) and 4 h (7.41 +/- 2.5 m s(-1)) respectively, in the control trial (P < 0.05). There was no change in PWV at 3 h (5.36 +/- 1.1 m s(-1)) or 4 h (5.95 +/- 2.3 m s(-1)) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 h post ingestion in the exercise trial compared to levels at 3 h (P < 0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in the exercise trial (0.52 +/- 0.05 vs. 0.41 +/- 0.1 units mul(-1); P < 0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairments in arterial function by possibly reducing oxidative stress levels.
氧化应激被认为是餐后血管功能受损的原因。本研究的目的是测量一次急性中等强度运动前后的脉搏波速度（PWV）和餐后氧化应激标志物。十名训练有素的男性受试者（年龄21.5±2.5岁，最大摄氧量58.5±7.1 ml·kg⁻¹·min⁻¹）参与了随机交叉设计：（1）仅高脂餐；（2）高脂餐后2小时进行1小时中等强度（最大心率的60%）运动。在基线、餐后1、2、3和4小时检测PWV。测量血脂过氧化物（LOOHs）、超氧化物歧化酶（SOD）和其他生化标志物。在对照试验中，PWV分别在餐后1小时（6.49±2.1 m·s⁻¹）、2小时（6.94±2.4 m·s⁻¹）、3小时（7.25±2.1 m·s⁻¹）和4小时（7.41±2.5 m·s⁻¹）升高（P<0.05）。在运动试验中，摄入后3小时（5.36±1.1 m·s⁻¹）或4小时（5.95±2.3 m·s⁻¹）PWV没有变化（P>0.05）。与对照试验中3小时的水平相比，运动试验中摄入后3小时LOOH水平降低（P<0.05）。与运动试验中3小时相比，对照试验中摄入后3小时SOD水平较低（0.52±0.05对0.41±0.1单位·μl⁻¹；P<0.05）。这些发现表明，单次有氧运动可能通过降低氧化应激水平来改善餐后动脉功能障碍。
