Ahn Jong-Woong, Jang Kyoung Hwa, Yang Hyeong-Cheol, Oh Ki-Bong, Lee Hyi-Seung, Shin Jongheon
Division of Marine Environment & Bioscience, College of Ocean Science and Technology, Korea Maritime University, Youngdo, Busan, Korea.
Chem Pharm Bull (Tokyo). 2007 Mar;55(3):477-9. doi: 10.1248/cpb.55.477.
Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
从韩国土壤中采集的滑行细菌黄褐粘球菌的培养液中分离出两种新的联噻唑代谢产物（3, 4）以及先前报道的化合物（1, 2）。基于综合光谱分析，确定这些化合物的结构与粘噻唑A类似。新化合物分别对小鼠成纤维细胞系L929和白色念珠菌表现出显著的细胞毒性和中等程度的抗真菌活性。这些数据与之前的发现一致，即粘噻唑类化合物的生物活性高度依赖于末端甲氧基烯醇官能团的存在。
