Fischbein A, Luo J C, Solomon S J, Horowitz S, Hailoo W, Miller A
Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine, City University of New York, New York 10029.
Br J Ind Med. 1992 Jan;49(1):17-24. doi: 10.1136/oem.49.1.17.
In 1940, the first report appeared describing a pulmonary disorder associated with occupational exposures in the cemented tungsten carbide industry. The disease, known as "hard metal disease," has subsequently been characterised in detail and comprises a wide range of clinical signs and symptoms. In this report, clinical findings in a group of 41 hard metal workers employed until recently are described. A high prevalence of respiratory symptoms was found. Thirteen workers (31%) had abnormal chest radiographs indicative of interstitial lung disease. Fifty per cent of these had been employed in hard metal manufacturing for less than 10 years. Abnormalities of pulmonary function were also frequent and included a restrictive pattern of impairment and decrease in diffusing capacity (27%). Associations were found between diffusing capacity, chest radiographic abnormalities and right ventricular ejection fraction at exercise indicating cardiopulmonary effects. The findings show the continuous need to control excessive occupational exposures to prevent hard metal disease, the history of which now enters its sixth decade.
1940年,首篇报告问世,描述了一种与硬质合金行业职业暴露相关的肺部疾病。这种疾病被称为“硬质金属病”,随后得到了详细的特征描述,涵盖了广泛的临床体征和症状。在本报告中,描述了一组直至近期仍受雇的41名硬质金属工人的临床检查结果。发现呼吸道症状的患病率很高。13名工人(31%)胸部X光片异常,提示间质性肺病。其中50%受雇于硬质金属制造业的时间不足10年。肺功能异常也很常见,包括限制性损害模式和弥散能力下降(27%)。运动时发现弥散能力、胸部X光片异常与右心室射血分数之间存在关联,表明存在心肺效应。研究结果表明,持续需要控制过度的职业暴露以预防硬质金属病,该病的历史现已进入第六个十年。