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一名新生儿出现短暂性心脏传导阻滞,与先前未诊断出的母体抗Ro/SSA和抗La/SSB抗体有关。

Transient heart block in a neonate associated with previously undiagnosed maternal anti-Ro/SSA and anti-La/SSB antibodies.

作者信息

Escamilla S A, Pettersen M D

机构信息

Pediatric Cardiology at Children's Hospital of Michigan, Detroit, MI 48201, USA.

出版信息

Pediatr Cardiol. 2007 May-Jun;28(3):221-3. doi: 10.1007/s00246-006-0015-2. Epub 2007 Mar 20.

DOI:10.1007/s00246-006-0015-2
PMID:17375353
Abstract

This report presents the case of an infant who was born with transient complete heart block. The cardiac rhythm converted to normal sinus rhythm within 12 hours of life. Following the diagnosis in this infant of congenital heart block, both the mother and the infant were tested for autoantibodies. Both were found to be strongly positive for anti-Ro/SSA antibodies. The infant was also weakly positive for the anti-La/SSB antibodies and her mother moderately positive for the same. Congenital heart block associated with these maternal antibodies is well documented in the literature; however, this is the only reported case that documents a transient nature of the complete heart block.

摘要

本报告介绍了一名出生时患有暂时性完全性心脏传导阻滞的婴儿病例。该婴儿的心律在出生后12小时内转为正常窦性心律。在诊断出该婴儿患有先天性心脏传导阻滞后,对母亲和婴儿都进行了自身抗体检测。结果发现两人的抗Ro/SSA抗体均呈强阳性。婴儿的抗La/SSB抗体呈弱阳性,其母亲的该抗体呈中度阳性。文献中已充分记载了与这些母体抗体相关的先天性心脏传导阻滞;然而,这是唯一一例记录了完全性心脏传导阻滞具有暂时性的报告病例。

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本文引用的文献

1
Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block.抗SSA/Ro和抗SSB/La抗体介导的先天性心脏传导阻滞。
Lupus. 2005;14(9):660-4. doi: 10.1191/0961203305lu2195oa.
2
Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options.抗SSA/Ro抗体与心脏:仅仅是完全性先天性心脏传导阻滞吗?心电图及心肌异常与治疗选择综述
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Endocardial fibroelastosis associated with maternal anti-Ro and anti-La antibodies in the absence of atrioventricular block.
在无房室传导阻滞情况下与母体抗Ro和抗La抗体相关的心内膜弹力纤维增生症
J Am Coll Cardiol. 2002 Aug 21;40(4):796-802. doi: 10.1016/s0735-1097(02)02004-1.
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Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis.母体抗Ro和抗La抗体相关的心内膜弹力纤维增生症。
Circulation. 2002 Feb 19;105(7):843-8. doi: 10.1161/hc0702.104182.
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Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women.通过对流免疫电泳检测出抗Ro/SSA抗体的母亲所生新生儿患先天性完全性心脏传导阻滞的风险:一项针对100名女性的前瞻性研究。
Arthritis Rheum. 2001 Aug;44(8):1832-5. doi: 10.1002/1529-0131(200108)44:8<1832::AID-ART320>3.0.CO;2-C.
6
Increase in the heart rate-corrected QT interval in children of anti-Ro-positive mothers, with a further increase in those with siblings with congenital heart block: comment on the article by Cimaz et al.抗Ro抗体阳性母亲的子女心率校正QT间期增加,其患有先天性心脏传导阻滞的兄弟姐妹的子女增加更为明显:对Cimaz等人文章的评论
Arthritis Rheum. 2001 Jan;44(1):242-3. doi: 10.1002/1529-0131(200101)44:1<242::AID-ANR34>3.0.CO;2-S.
7
Congenital heart block: development of late-onset cardiomyopathy, a previously underappreciated sequela.先天性心脏传导阻滞:迟发性心肌病的发展,一种先前未得到充分认识的后遗症。
J Am Coll Cardiol. 2001 Jan;37(1):238-42. doi: 10.1016/s0735-1097(00)01048-2.
8
Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages.抗SSA/Ro和抗SSB/La自身抗体结合凋亡胎儿心肌细胞表面,并促进巨噬细胞分泌肿瘤坏死因子-α。
J Immunol. 2000 Nov 1;165(9):5345-51. doi: 10.4049/jimmunol.165.9.5345.
9
QT interval prolongation in asymptomatic anti-SSA/Ro-positive infants without congenital heart block.无症状的抗SSA/Ro抗体阳性且无先天性心脏传导阻滞的婴儿出现QT间期延长。
Arthritis Rheum. 2000 May;43(5):1049-53. doi: 10.1002/1529-0131(200005)43:5<1049::AID-ANR13>3.0.CO;2-X.
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Fetal treatment of congenital heart block ascribed to anti-SSA antibody: case reports with observation of cardiohemodynamics and review of the literature.胎儿先天性心脏传导阻滞归因于抗SSA抗体的治疗:病例报告及心脏血流动力学观察与文献复习
Am J Reprod Immunol. 1999 Oct;42(4):226-32. doi: 10.1111/j.1600-0897.1999.tb00095.x.