Lazo John S, Brady Linda S, Dingledine Ray
Department of Pharmacology, Pittsburgh Molecular Library Screening Center, University of Pittsburgh, Biomedical Science Tower 3, Suite 10040, Pittsburgh, PA 15261-0001, USA.
Mol Pharmacol. 2007 Jul;72(1):1-7. doi: 10.1124/mol.107.035113. Epub 2007 Apr 3.
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of molecular pharmacology with contemporary high-throughput and high-content screening technologies is essential for the success of these discovery activities. We present some of the challenges and opportunities provided by the Molecular Library Screening Centers Network (MLSCN), which is a National Institutes of Health Roadmap Initiative.
小分子是剖析生物事件的强大药理学工具。目前，人们对加大力度识别和使用针对人类及致病生物体基因组中编码蛋白质的小分子兴趣浓厚。将分子药理学原理与当代高通量和高内涵筛选技术相结合，对于这些发现活动的成功至关重要。我们介绍了分子文库筛选中心网络（MLSCN）带来的一些挑战和机遇，该网络是美国国立卫生研究院路线图计划的一部分。
