Valcheva-Kuzmanova Stefka V, Belcheva Anna
Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, Varna, Bulgaria.
Folia Med (Plovdiv). 2006;48(2):11-7.
Aronia melanocarpa, native to eastern North America, has become popular in Eastern Europe and Russia. Aronia melanocarpa fruits are one of the richest plant sources of phenolic substances, mainly anthocyanins--glycosides of cyanidin. Anthocyanins are water soluble pigments accounting for the dark blue and even black color of the fruits. Administered orally they can be absorbed as intact glycosides. Aronia melanocarpa fruit juice and anthocyanins derived from the fruits have been studied intensively for the last 15 years. Most of the effects of Aronia melanocarpa anthocyanins are due to their high antioxidative activity. Our investigations have demonstrated a remarkable hepatoprotective, a very good gastroprotective and a pronounced anti-inflammatory effect of Aronia melanocarpa fruit juice in rats as well as a bacteriostatic activity in vitro against Staphylococcus aureus and Escherichia coli and an antiviral activity against type A influenza virus. Research of other authors has demonstrated that Aronia melanocarpa anthocyanins can normalize the carbohydrate metabolism in diabetic patients and in streptozotocin-diabetic rats, have an in vitro antimutagenic activity and exhibit a distinct immunomodulatory activity in human lymphocyte cultures and in patients with breast cancer, suppress the growth of human HT-29 colon cancer cells, inhibit the N-nitrosamine formation in rats and decrease the toxicity and cumulation of cadmium in liver and kidneys. Currently, there are no data in literature about any unwanted and toxic effects of Aronia melanocarpa fruits, juice and extracts.
黑果腺肋花楸原产于北美东部，在东欧和俄罗斯颇受欢迎。黑果腺肋花楸果实是酚类物质最丰富的植物来源之一，主要是花青素——矢车菊素的糖苷。花青素是水溶性色素，赋予果实深蓝色甚至黑色。口服时，它们可以作为完整的糖苷被吸收。在过去15年里，人们对黑果腺肋花楸果汁和从果实中提取的花青素进行了深入研究。黑果腺肋花楸花青素的大部分功效归因于其高抗氧化活性。我们的研究表明，黑果腺肋花楸果汁对大鼠具有显著的肝脏保护、良好的胃保护和明显的抗炎作用，以及对金黄色葡萄球菌和大肠杆菌的体外抑菌活性和对甲型流感病毒的抗病毒活性。其他作者的研究表明，黑果腺肋花楸花青素可以使糖尿病患者和链脲佐菌素诱导的糖尿病大鼠的碳水化合物代谢正常化，具有体外抗诱变活性，并在人淋巴细胞培养物和乳腺癌患者中表现出明显的免疫调节活性，抑制人HT - 29结肠癌细胞的生长，抑制大鼠体内N -亚硝胺的形成，并降低肝脏和肾脏中镉的毒性和蓄积。目前，文献中没有关于黑果腺肋花楸果实、果汁和提取物任何不良和毒性作用的数据。
