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Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.正常小鼠血清中天然存在的一种可溶性非免疫球蛋白因子介导的病毒特异性中和作用。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5071-5. doi: 10.1073/pnas.72.12.5071.
2
Autogenous immunity to endogenous RNA tumor virus: humoral immune response to virus envelope antigens.对内源性RNA肿瘤病毒的自身免疫：对病毒包膜抗原的体液免疫反应。
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Xenotropic C-type viruses and autoimmune disease.嗜异性C型病毒与自身免疫性疾病
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Xenotropic C-type viruses and autoimmune disease.嗜异性C型病毒与自身免疫性疾病。
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本文引用的文献

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QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES.抗体琼脂平板中血清免疫球蛋白的定量测定
J Immunol. 1965 Jan;94:84-90.
2
Persistent infection of a rat kidney cell line with Rauscher murine leukemia virus.劳氏鼠白血病病毒对大鼠肾细胞系的持续感染。
J Bacteriol. 1966 Oct;92(4):1133-40. doi: 10.1128/jb.92.4.1133-1140.1966.
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Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
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Autoimmunity and neoplasia. The possible role of C-type viruses.自身免疫与肿瘤形成。C型病毒的可能作用。
Am J Clin Pathol. 1974 Aug;62(2):258-80. doi: 10.1093/ajcp/62.2.258.
5
Widespread natural occurrence of high titers of neutralizing antibodies to a specific class of endogenous mouse type-C virus.广泛自然存在针对一类特定内源性小鼠C型病毒的高滴度中和抗体。
Proc Natl Acad Sci U S A. 1974 May;71(5):1957-61. doi: 10.1073/pnas.71.5.1957.
6
Evidence that the AKR murine-leukemia-virus genome is complete in DNA of the high-virus AKR mouse and incomplete in the DNA of the "virus-negative" NIH mouse.有证据表明，AKR鼠白血病病毒基因组在高病毒血症AKR小鼠的DNA中是完整的，而在“病毒阴性”NIH小鼠的DNA中是不完整的。
Proc Natl Acad Sci U S A. 1974 Jan;71(1):167-71. doi: 10.1073/pnas.71.1.167.
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[Demonstration of an antiviral substance in the culture medium of cells of the NZB mouse].
C R Acad Hebd Seances Acad Sci D. 1973 Oct 8;277(14):1421-3.
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Genetic factors in the natural history of murine leukemia virus infection: G. H. A. Clowes Memorial Lecture.鼠白血病病毒感染自然史中的遗传因素：G. H. A. 克劳斯纪念讲座
Cancer Res. 1973 Dec;33(12):3061-8.
9
Xenotropic viruses: murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains.嗜异性病毒：与美国国立卫生研究院瑞士小鼠、新西兰黑小鼠及其他小鼠品系相关的鼠白血病病毒。
Science. 1973 Dec 14;182(4117):1151-3. doi: 10.1126/science.182.4117.1151.
10
Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells.小鼠细胞中生物可区分的RNA C型病毒激活位点的独立分离。
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2055-8. doi: 10.1073/pnas.70.7.2055.

正常小鼠血清中天然存在的一种可溶性非免疫球蛋白因子介导的病毒特异性中和作用。

Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.

作者信息

Levy J A, Ihle J N, Oleszko O, Barnes R D

出版信息

Proc Natl Acad Sci U S A. 1975 Dec;72(12):5071-5. doi: 10.1073/pnas.72.12.5071.

DOI:10.1073/pnas.72.12.5071
PMID:174092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388877/
Abstract

A low-molecular-weight substance found naturally in mouse serum neutralizes mouse xenotropic C-type virus. It has no effect on endogenous ecotropic viruses. This neutralizing factor does not belong to the known immunogloblin classes, and its activity is not associated with the antivirus immunoglobulins that can be detected by radioimmunoprecipitation. Preparations of xenotropic virus absorb out this neutralizing activity in mouse sera. The specificity of this factor for X-tropic virus suggests that it represents a newly recognized type of response of the host to an endogenous virus. Its possible role in the regulation of endogenous C-type viruses is considered.

摘要

在小鼠血清中天然存在的一种低分子量物质可中和小鼠嗜异源性C型病毒。它对内源性亲嗜性病毒没有影响。这种中和因子不属于已知的免疫球蛋白类别，其活性与可通过放射免疫沉淀检测到的抗病毒免疫球蛋白无关。嗜异源性病毒制剂可去除小鼠血清中的这种中和活性。该因子对X嗜性病毒的特异性表明它代表了宿主对一种内源性病毒新认识的反应类型。文中考虑了其在内源性C型病毒调节中的可能作用。