正常小鼠血清中天然存在的一种可溶性非免疫球蛋白因子介导的病毒特异性中和作用。
Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.
作者信息
Levy J A, Ihle J N, Oleszko O, Barnes R D
出版信息
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5071-5. doi: 10.1073/pnas.72.12.5071.
Abstract
A low-molecular-weight substance found naturally in mouse serum neutralizes mouse xenotropic C-type virus. It has no effect on endogenous ecotropic viruses. This neutralizing factor does not belong to the known immunogloblin classes, and its activity is not associated with the antivirus immunoglobulins that can be detected by radioimmunoprecipitation. Preparations of xenotropic virus absorb out this neutralizing activity in mouse sera. The specificity of this factor for X-tropic virus suggests that it represents a newly recognized type of response of the host to an endogenous virus. Its possible role in the regulation of endogenous C-type viruses is considered.
摘要
在小鼠血清中天然存在的一种低分子量物质可中和小鼠嗜异源性C型病毒。它对内源性亲嗜性病毒没有影响。这种中和因子不属于已知的免疫球蛋白类别，其活性与可通过放射免疫沉淀检测到的抗病毒免疫球蛋白无关。嗜异源性病毒制剂可去除小鼠血清中的这种中和活性。该因子对X嗜性病毒的特异性表明它代表了宿主对一种内源性病毒新认识的反应类型。文中考虑了其在内源性C型病毒调节中的可能作用。
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