Esparza José, Yamada Tadataka
Bill & Melinda Gates Foundation, Seattle, WA 98102, USA.
J Exp Med. 2007 Apr 16;204(4):701-4. doi: 10.1084/jem.20070073. Epub 2007 Apr 9.
The increasing complexity of biomedical research is leading to the exploration of new models for large-scale collaborative research. This Big Science approach, however, has created anxieties and potential tensions between investigator-driven research, and research guided by a more organized, collaborative effort. Another potential tension exists between research conducted purely in search of new knowledge and research aimed at finding solutions. We argue that big biomedicine--the work of coordinated multidisciplinary groups that use the latest technologies to solve complex problems--can be an important way to harness the creativity of individual investigators, stimulate innovation, and supply the infrastructure, experimental systems, and resources needed to solve the urgent health problems confronted by our global society. We discuss this using the example of the Global HIV Vaccine Enterprise.
生物医学研究日益复杂，促使人们探索大规模合作研究的新模式。然而，这种“大科学”方法在研究者主导的研究与更有组织的合作努力所引导的研究之间引发了焦虑和潜在的紧张关系。在纯粹为寻求新知识而进行的研究与旨在寻找解决方案的研究之间，也存在另一种潜在的紧张关系。我们认为，大型生物医学——由多学科团队协同开展、运用最新技术解决复杂问题的工作——可以成为发挥个体研究者创造力、激发创新并提供解决全球社会所面临紧迫健康问题所需的基础设施、实验系统和资源的重要途径。我们将以全球艾滋病毒疫苗企业为例进行讨论。
